Vestibular and Hearing Manifestations of Phenytoin Toxicity: A Retrospective Series

We undertook a study to identify the vestibular and hearing abnormalities associated with phenytoin toxicity. Since October 1977, 23 patients with phenytoin toxicity have been referred to the Department of Otorhinolaryngology by the Department of Neurology for electro-oculographic (EOG) evaluation....

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Bibliographic Details
Published inEar, nose, & throat journal Vol. 80; no. 6; pp. 404 - 409
Main Authors De Diego, Juan I., Prim, Maria P., Marcos, Sol, De Sarria, Maria J., Arpa, Javier, Gavilan, Javier
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.06.2001
Medquest Communications
Sage Publications, Inc
SAGE PUBLICATIONS, INC
Subjects
Adolescent
Adult
Age Distribution
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Biological and medical sciences
Complications and side effects
Drug toxicity and drugs side effects treatment
Female
Hearing
Hearing Disorders - chemically induced
Humans
Incidence
Male
Medical sciences
Medicine
Middle Aged
Otolaryngology
Pharmacology. Drug treatments
Phenytoin
Phenytoin - adverse effects
Phenytoin - therapeutic use
Practice
Prognosis
Retrospective Studies
Risk Assessment
Risk Factors
Seizures - drug therapy
Sex Distribution
Toxicity: respiratory system, ent, stomatology
Vestibular Diseases - chemically induced
United States
Human
Peripheral vestibular syndrome
Chemotherapy
Treatment
Toxicity
Internal ear disease
Auditory disorder
ENT disease
Anticonvulsant
Phenytoin
Hearing loss
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Summary:We undertook a study to identify the vestibular and hearing abnormalities associated with phenytoin toxicity. Since October 1977, 23 patients with phenytoin toxicity have been referred to the Department of Otorhinolaryngology by the Department of Neurology for electro-oculographic (EOG) evaluation. (There have been no cases of serious phenytoin toxicity seen in our department since August 1989.) In addition to EOG, all patients had undergone otoscopic, audiometric, and neurologic examinations. We found that the most common pathologic findings detected by EOG were abnormalities in pursuit tracking. The most common signs found on clinical exploration were cerebellar dysfunction and facial palsy. EOG findings in patients with phenytoin toxicity are compatible with cerebellar disease.
ISSN:0145-5613
1942-7522
DOI:10.1177/014556130108000610