Emerging themes in medicinal glycoscience

• Published in: Nature biotechnology Vol. 18; no. 8; pp. 835 - 841
• Main Authors: Wong, Chi-Huey, Koeller, Kathryn M
• Format: Journal Article
• Language: English
• Published: New York, NY Nature 01.08.2000; Nature Publishing Group
• Subjects: Anti-Infective Agents - chemistry; Anti-Infective Agents - therapeutic use; Biological and medical sciences; Biotechnology; Carbohydrate Sequence; Carbohydrates; Enzymes; Fundamental and applied biological sciences. Psychology; glycoconjugates; Glycoconjugates - chemistry; Glycoconjugates - therapeutic use; Glycoproteins; Health. Pharmaceutical industry; Humans; Industrial applications and implications. Economical aspects; Influenza; Molecular Sequence Data; Other active biomolecules; Peptides; Production of active biomolecules; Proteins; Signal transduction; Vaccines; Enzymatic synthesis; Industrial application; Antiviral; Graft; Vaccine; Review; Glycoconjugate; Pharmaceutical industry; Chemical synthesis; Antimicrobial agent; Medical application
• ISSN: 1087-0156; 1546-1696
• DOI: 10.1038/78435

The recognition of complex carbohydrates and glycoconjugates as mediators of important biological processes has stimulated investigation into their therapeutic potential. New approaches for the simplification of glycoconjugate synthesis are overcoming the limitations of existing methods and providing a diverse array of these biomolecules. As the accessibility of glycoconjugates increases, carbohydrate-based constructs are becoming available for analysis as medicinal agents in a wide range of therapies.