Panapophenanthrin, a Rare Oligocyclic Diterpene from Panus strigellus

• Published in: Metabolites Vol. 13; no. 7; p. 848
• Main Authors: Llanos-López, Natalia A, Ebada, Sherif Saeed, Vasco-Palacios, Aída M, Sánchez-Giraldo, Laura M, López, Lina, Rojas, Luisa F, Mándi, Attila, Kurtán, Tibor, Marin-Felix, Yasmina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.07.2023; MDPI
• Subjects: Absolute configuration; Adenocarcinoma; antimicrobial; basidiomycota; Biological activity; Cytotoxicity; Fermentation; Glucose; Hydrocarbons; Ions; Mass spectroscopy; Metabolites; Morphology; NMR; Nuclear magnetic resonance; PCB; Phylogenetics; Polychlorinated biphenyls; Secondary metabolites; white rot fungi; Colombia; United States > US; Germany; antimicrobial; white rot fungi; secondary metabolites; basidiomycota; cytotoxicity
• ISSN: 2218-1989; 2218-1989
• DOI: 10.3390/metabo13070848

During the course of our search for biologically active secondary metabolites from fungal cultures, a new oligocyclic diterpenoidal derivative, panapophenanthrin ( ), was isolated from . In addition, two known metabolites, panepophenanthrin ( ) and dihydrohypnophilin ( ), were also obtained. The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectral analyses together with high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configuration was determined through TDDFT-ECD calculations. All of the compounds were assessed for their antimicrobial and cytotoxic activities. Compounds and showed moderate to weak activities in the performed antimicrobial assays, while compound exhibited potent cytotoxic activity against the mammalian cell lines mouse fibroblast (L929) and human endocervical adenocarcinoma (KB3.1).