Metabolites of Geum aleppicum and Sibbaldianthe bifurca : Diversity and α-Glucosidase Inhibitory Potential

• Published in: Metabolites Vol. 13; no. 6; p. 689
• Main Authors: Kashchenko, Nina I, Olennikov, Daniil N, Chirikova, Nadezhda K
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2023; MDPI
• Subjects: Acids; avens; Carbohydrates; Chromatography; Diabetes; Diabetes mellitus; Ellagic acid; Flavonoids; Flowering; Flowers & plants; Fruits; Geum aleppicum; Herbs; High-performance liquid chromatography; Ionization; Ions; Metabolites; Organic acids; Plants; Potentilla bifurca; Quercetin; Rosaceae; Sibbaldianthe bifurca; Triterpenoids; α-Glucosidase; Buryatia Russia; United States > US; China; Russia; ellagitannins; Potentilla bifurca; Rosaceae; HPLC activity-based profiling; gemin A; high-performance liquid chromatography; avens; flavonoids; Geum aleppicum; diabetes
• ISSN: 2218-1989; 2218-1989
• DOI: 10.3390/metabo13060689

α-Glucosidase inhibitors are essential in the treatment of diabetes mellitus. Plant-derived drugs are promising sources of new compounds with glucosidase-inhibiting ability. The Jacq. and (L.) Kurtto & T.Erikss. herbs are used in many traditional medical systems to treat diabetes. In this study, metabolites of the and herbs in active growth, flowering, and fruiting stages were investigated using high-performance liquid chromatography with photodiode array and electrospray ionization triple quadrupole mass spectrometric detection (HPLC-PDA-ESI-tQ-MS/MS). In total, 29 compounds in and 41 components in were identified including carbohydrates, organic acids, benzoic and ellagic acid derivatives, ellagitannins, flavonoids, and triterpenoids. Gemin A, miquelianin, niga-ichigoside F1, and 3,4-dihydroxybenzoic acid 4- -glucoside were the dominant compounds in the herb, while guaiaverin, miquelianin, tellimagrandin II , casuarictin, and glucose were prevailing compounds in the herb. On the basis of HPLC activity-based profiling of the herb extract, the most pronounced inhibition of α-glucosidase was observed for gemin A and quercetin-3- -glucuronide. The latter compound and quercetin-3- -arabinoside demonstrated maximal inhibition of α-glucosidase in the herb extract. The obtained results confirm the prospects of using these plant compounds as possible sources of hypoglycemic nutraceuticals.