NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis
To assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n = 177) were randomly divided into three groups t...
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Published in | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Vol. 25; no. 7; pp. 872 - 884 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Taylor & Francis Group
01.07.2008
Taylor & Francis |
Subjects | |
Online Access | Get full text |
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Summary: | To assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n = 177) were randomly divided into three groups that received 3.0 g NS day-1 (high dose, HD), 1.5 g NS day-1 (low dose, LD), or placebo (PL). Levels of vitamins A and E in serum were comparable among the three study groups at baseline, 1 month and 3 months of NS intervention. Gender-stratified non-parametric mixed-effect model analysis showed no significant effects of dose and dose-time interaction for levels of vitamins A and E. A significant time effect was detected; however, it was limited to an increase in vitamin E in the male participants over the course of the study. No significant differences were found in levels of the nutrient and non-nutrient minerals between the HD and PL groups at baseline and 3 months of NS intervention, except for strontium levels. Strontium was significantly increased (p < 0.001) in the HD group (male = 113.65 ± 28.00 μg l-1; female = 116.40 ± 24.26 μg l-1) compared with the PL group (male = 83.55 ± 39.90 μg l-1; female = 90.47 ± 25.68 μg l-1) following the 3-month intervention with NS. These results, combined with safety and efficacy data, confirm that NS clay is highly effective in reducing aflatoxin exposure and acts as a selective enterosorbent that does not affect the serum concentrations of important vitamins and nutrient minerals in humans. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0265-203X 1944-0049 1464-5122 1944-0057 |
DOI: | 10.1080/02652030701854758 |