Screening for Prostate Cancer Decreases the Risk of Developing Metastatic Disease: Findings from the European Randomized Study of Screening for Prostate Cancer (ERSPC)

• Published in: European urology Vol. 62; no. 5; pp. 745 - 752
• Main Authors: Schröder, Fritz H, Hugosson, Jonas, Carlsson, Sigrid, Tammela, Teuvo, Määttänen, Liisa, Auvinen, Anssi, Kwiatkowski, Maciej, Recker, Franz, Roobol, Monique J
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.11.2012; Elsevier
• Subjects: Biological and medical sciences; Cancer and Oncology; Cancer och onkologi; Early Detection of Cancer; Europe - epidemiology; Gynecology. Andrology. Obstetrics; Humans; Incidence; Kallikreins - blood; Male; Male genital diseases; Mass screening; Mass Screening - methods; Medical sciences; Middle Aged; Neoplasm metastases; Nephrology. Urinary tract diseases; Predictive Value of Tests; Prognosis; Prostate-Specific Antigen - blood; Prostatic neoplasm; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - secondary; Prostatic Neoplasms - therapy; Risk Assessment; Risk Factors; Time Factors; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urologi och njurmedicin; Urology; Urology and Nephrology; Europe; Neoplasm metastases; Mass screening; Prostatic neoplasm; Prostate tumor; Nephrology; Urinary system disease; Prostate disease; Disease; Malignant tumor; Metastasis; Medical screening; Urology; Prevention; Randomization; Decrease; Risk factor; Advanced stage; Metastatic; Male genital diseases; Prostate cancer; Cancer
• ISSN: 0302-2838; 1873-7560; 1873-7560
• DOI: 10.1016/j.eururo.2012.05.068

Abstract Background Metastatic disease is a major morbidity of prostate cancer (PCa). Its prevention is an important goal. Objective To assess the effect of screening for PCa on the incidence of metastatic disease in a randomized trial. Design, setting, and participants Data were available for 76 813 men aged 55–69 yr coming from four centers of the European Randomized Study of Screening for Prostate Cancer (ERSPC). The presence of metastatic disease was evaluated by imaging or by prostate-specific antigen (PSA) values >100 ng/ml at diagnosis and during follow-up. Intervention Regular screening based on serum PSA measurements was offered to 36 270 men randomized to the screening arm, while no screening was provided to the 40 543 men in the control arm. Outcome measurements and statistical analysis The Nelson-Aalen technique and Poisson regression were used to calculate cumulative incidence and rate ratios of M+ disease. Results and limitations After a median follow-up of 12 yr, 666 men with M+ PCa were detected, 256 in the screening arm and 410 in the control arm, resulting in cumulative incidence of 0.67% and 0.86% per 1000 men, respectively ( p < 0.001). This finding translated into a relative reduction of 30% (hazard ratio [HR]: 0.70; 95% confidence interval [CI], 0.60–0.82; p = 0.001) in the intention-to-screen analysis and a 42% ( p = 0.0001) reduction for men who were actually screened. An absolute risk reduction of metastatic disease of 3.1 per 1000 men randomized (0.31%) was found. A large discrepancy was seen when comparing the rates of M+ detected at diagnosis and all M+ cases that emerged during the total follow-up period, a 50% reduction (HR: 0.50; 95% CI, 0.41–0.62) versus the 30% reduction. The main limitation is incomplete explanation of the lack of an effect of screening during follow-up. Conclusions PSA screening significantly reduces the risk of developing metastatic PCa. However, despite earlier diagnosis with screening, certain men still progress and develop metastases. The ERSPC trial is registered under number ISRCTN49127736.