Mitochondria in Ischemic Stroke: New Insight and Implications

Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement...

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Bibliographic Details
Published inAging and disease Vol. 9; no. 5; pp. 924 - 937
Main Authors Liu, Fan, Lu, Jianfei, Manaenko, Anatol, Tang, Junjia, Hu, Qin
Format Journal Article
LanguageEnglish
Published United States JKL International 01.10.2018
JKL International LLC
Subjects
Care and treatment
Complications and side effects
Development and progression
Health aspects
Mitochondria
Physiological aspects
Review
Stroke
mitochondrial transfer
mitochondrial quality control
mitophagy
Ischemic stroke
neuroprotection
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Summary:Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2017.1126