One-pot microbial synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase
A one-pot enzymatic synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase was established. Glycolysis by baker's yeast (Saccharomyces cerevisiae) generated ATP which was used to produce D: -glyceraldehyde 3-phosphate production from glucose via fructose 1,6-dipho...
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| Published in | Biotechnology letters Vol. 28; no. 12; pp. 877 - 881 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer
01.06.2006
Springer Nature B.V |
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| Abstract | A one-pot enzymatic synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase was established. Glycolysis by baker's yeast (Saccharomyces cerevisiae) generated ATP which was used to produce D: -glyceraldehyde 3-phosphate production from glucose via fructose 1,6-diphosphate. The D: -glyceraldehyde 3-phosphate produced was transformed to 2'-deoxyribonucleoside via 2-deoxyribose 5-phosphate and then 2-deoxyribose 1-phosphate in the presence of acetaldehyde and a nucleobase by deoxyriboaldolase, phosphopentomutase expressed in Escherichia coli, and a commercial nucleoside phosphorylase. About 33 mM 2'-deoxyinosine was produced from 600 mM glucose, 333 mM acetaldehyde and 100 mM adenine in 24 h. 2'-Deoxyinosine was produced from adenine due to the adenosine deaminase activity of E. coli transformants. |
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| AbstractList | A one-pot enzymatic synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase was established. Glycolysis by baker's yeast (Saccharomyces cerevisiae) generated ATP which was used to produce d-glyceraldehyde 3-phosphate production from glucose via fructose 1,6-diphosphate. The d-glyceraldehyde 3-phosphate produced was transformed to 2'-deoxyribonucleoside via 2-deoxyribose 5-phosphate and then 2-deoxyribose 1-phosphate in the presence of acetaldehyde and a nucleobase by deoxyriboaldolase, phosphopentomutase expressed in Escherichia coli, and a commercial nucleoside phosphorylase. About 33 mM 2'-deoxyinosine was produced from 600 mM glucose, 333 mM acetaldehyde and 100 mM adenine in 24 h. 2'-Deoxyinosine was produced from adenine due to the adenosine deaminase activity of E. coli transformants.[PUBLICATION ABSTRACT] A one-pot enzymatic synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase was established. Glycolysis by baker's yeast (Saccharomyces cerevisiae) generated ATP which was used to produce d-glyceraldehyde 3-phosphate production from glucose via fructose 1,6-diphosphate. The d-glyceraldehyde 3-phosphate produced was transformed to 2'-deoxyribonucleoside via 2-deoxyribose 5-phosphate and then 2-deoxyribose 1-phosphate in the presence of acetaldehyde and a nucleobase by deoxyriboaldolase, phosphopentomutase expressed in Escherichia coli, and a commercial nucleoside phosphorylase. About 33 mM 2'-deoxyinosine was produced from 600 mM glucose, 333 mM acetaldehyde and 100 mM adenine in 24 h. 2'-Deoxyinosine was produced from adenine due to the adenosine deaminase activity of E. coli transformants. |
| Author | MIKAMI, Yoichi SASAKI, Mie KAWANO, Takako SAKAI, Takafumi HORINOUCHI, Nobuyuki SAITO, Kyota SHIMIZU, Sakayu OGAWA, Jun MATSUMOTO, Seiichiro |
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| Cites_doi | 10.1016/S1381-1177(00)00121-1 10.1098/rspb.1906.0029 10.1128/AEM.69.7.3791-3797.2003 10.1271/bbb.67.933 10.1128/AEM.64.8.2952-2957.1998 10.1007/s00253-005-0205-5 10.1271/bbb.67.989 10.1016/0378-1119(82)90145-7 |
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| Keywords | Deoxyribose-phosphate aldolase Yeast Nucleoside phosphorylase Phosphopentomutase Glycosyltransferases Lyases Deoxyribonucleoside Glucose Acetaldehyde Fungi Isomerases Nucleoside Ascomycetes Phosphotransferases Thallophyta Enzyme Transferases Aldehyde-lyases Phosphorylase Carbon-carbon lyases 2'-deoxyribonucleoside Intramolecular transferases Glycolysis Hexosyltransferases Microorganism Deoxyriboaldolase Saccharomyces cerevisiae |
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| References | M Fischer (9019_CR1) 1982; 17 K Okuyama (9019_CR6) 2003; 67 N Horinouchi (9019_CR3) 2003; 69 K Yokozaki (9019_CR9) 2000; 10 J Ogawa (9019_CR5) 2003; 67 A Harden (9019_CR2) 1905; 77 9019_CR4 T Tochikura (9019_CR7) 1967; 45 S Wakisaka (9019_CR8) 1998; 64 |
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| Snippet | A one-pot enzymatic synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase was established. Glycolysis by baker's yeast... |
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| SubjectTerms | Acetaldehyde - metabolism Biological and medical sciences Biotechnology Biotechnology - methods Deoxyribonucleosides - biosynthesis E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Glucose - metabolism Microbiology Pentosyltransferases - pharmacology Phosphotransferases - metabolism Ribosemonophosphates - metabolism Saccharomyces - enzymology Saccharomyces cerevisiae Transformation, Bacterial - genetics Transformation, Bacterial - physiology Yeast Yeasts |
| Title | One-pot microbial synthesis of 2'-deoxyribonucleoside from glucose, acetaldehyde, and a nucleobase |
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