Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake

• Published in: Carbohydrate polymers Vol. 90; no. 1; pp. 16 - 22
• Main Authors: Liu, Jinsong, Xu, Lihua, Liu, Chuantong, Zhang, Dafeng, Wang, Siqian, Deng, Zhennan, Lou, Weiwei, Xu, Haihong, Bai, Qing, Ma, Jianfeng
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2012; Elsevier
• Subjects: Antineoplastic agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; Applied sciences; Biological and medical sciences; Cations - chemistry; Cell Survival - drug effects; Cell uptake; cell viability; Chemotherapy; chitosan; Chitosan - chemistry; Chitosan/PCL; Curcumin; Curcumin - administration & dosage; Curcumin - pharmacokinetics; Curcumin - pharmacology; cytotoxicity; Delayed-Action Preparations - chemistry; drugs; encapsulation; Exact sciences and technology; fluorescence; HeLa Cells; Humans; In vitro cytotoxicity; Medical sciences; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Natural polymers; neoplasm cells; Neoplasms - drug therapy; Pharmacology. Drug treatments; Physicochemistry of polymers; Polyesters - chemistry; spectral analysis; Starch and polysaccharides; zeta potential; Nanoparticles; Cell uptake; Chitosan/PCL; Curcumin; In vitro cytotoxicity; Biological properties; Antineoplastic agent; Nanoparticle; Cytotoxicity; Drug carrier; Nanoencapsulation; Charged particle; Electrokinetic potential; Manufacturing; Polycaprolactone; Release; Polymer blends; Chemical precipitation; Control release polymer; Experimental study; In vitro; Hela cell line; Internalization; Oside polymer; Chitosan; Kinetics

► A simple nano-precipitation was employed to develop cationic curcumin nanoparticle. ► The cationic carrier was non-cytotoxic suitable for further in vivo application. ► The cationic curcumin nanoparticle greatly improve the cellular uptake of curcumin. In the present paper, cationic nanoparticles...