Sensitive and selective electrochemical determination of quinoxaline-2-carboxylic acid based on bilayer of novel poly(pyrrole) functional composite using one-step electro-polymerization and molecularly imprinted poly(o-phenylenediamine)

• Published in: Analytica chimica acta Vol. 806; pp. 136 - 143
• Main Authors: Yang, Yukun, Fang, Guozhen, Wang, Xiaomin, Pan, Mingfei, Qian, Hailong, Liu, Huilin, Wang, Shuo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 02.01.2014
• Subjects: Animals; Binuclear phthalocyanine cobalt(II) sulphonate; Chickens; Electrochemical sensor; Electrochemical Techniques; Electrodes; Elution; Glassy carbon; Graphene oxide; Graphite - chemistry; Imprinted polymers; Indoles - chemistry; Meat - analysis; Molecular Imprinting; Molecularly imprinted poly(o-phenylenediamine); Monomers; Phenylenediamines - chemistry; Poly(pyrrole); Polymerization; Polymers - chemistry; Pyrroles - chemistry; Quinoxaline-2-carboxylic acid; Quinoxalines - analysis; Recognition; Sensors; Swine; Voltammetry; Poly(pyrrole); Graphene oxide; Binuclear phthalocyanine cobalt(II) sulphonate; Molecularly imprinted poly(o-phenylenediamine); Electrochemical sensor; Quinoxaline-2-carboxylic acid
• ISSN: 0003-2670; 1873-4324
• DOI: 10.1016/j.aca.2013.11.023

•PPY-GO-BiCoPc composite was formed using a simple electrochemical method for the first time.•A novel PoPD-MIP sensor based on PPY-GO-BiCoPc composite had been fabricated.•The PPY-GO-BiCoPc functional composite was introduced to improve performance of the sensor.•Highly sensitive, selective and stable sensor had been achieved.•The established MIP sensor could be promising in food safety analysis. A facile and efficient molecularly imprinted polymer (MIP) recognition element of electrochemical sensor was fabricated by directly electro-polymerizing monomer o-phenylenediamine (oPD) in the presence of template quinoxaline-2-carboxylic acid (QCA), based on one-step controllable electrochemical modification of poly(pyrrole)-graphene oxide-binuclear phthalocyanine cobalt (II) sulphonate (PPY-GO-BiCoPc) functional composite on glassy carbon electrode (GCE). The MIP film coated on PPY-GO-BiCoPc functional composite decorated GCE (MIP/PPY-GO-BiCoPc/GCE) was presented for the first time. The synergistic effect and electro-catalytic activity toward QCA redox of PPY-GO-BiCoPc functional composite were discussed using various contrast tests. Also, the effect of experimental variables on the current response such as, electro-polymerization cycles, template/monomer ratio, elution condition for template removal, pH of the supporting electrolyte and accumulation time, were investigated in detail. Under the optimized conditions, the proposed MIP sensor possessed a fast rebinding dynamics and an excellent recognition capacity to QCA, while the anodic current response of square wave voltammetry (SWV) was well-proportional to the concentration of QCA in the range of 1.0×10−8–1.0×10−4 and 1.0×10−4–5.0×10−4molL−1 with a low detection limit of 2.1nmolL−1. The established sensor was applied successfully to determine QCA in commercial pork and chicken muscle samples with acceptable recoveries (91.6–98.2%) and satisfactory precision (1.9–3.5% of SD), demonstrating a promising feature for applying the MIP sensor to the measurement of QCA in real samples.