A reconstruction of early cryptic COVID spread
To respond better to future pandemics, we must understand how the SARS-CoV-2 virus dispersed so rapidly. A model of COVID-19 spread sheds light on cryptic transmission, undetected by surveillance efforts, in early 2020. Modelling undetected cases of infection at the start of the pandemic.
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Published in | Nature (London) Vol. 600; no. 7887; pp. 40 - 41 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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Nature Publishing Group UK
02.12.2021
Nature Publishing Group |
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Abstract | To respond better to future pandemics, we must understand how the SARS-CoV-2 virus dispersed so rapidly. A model of COVID-19 spread sheds light on cryptic transmission, undetected by surveillance efforts, in early 2020.
Modelling undetected cases of infection at the start of the pandemic. |
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AbstractList | Davis et al. used the Global Epidemic and Mobility (GLEAM) model, which has both stochastic (incorporating elements of randomness) and mechanistic (including defined principles about the biological and social mechanisms associated with viral infection and transmission) components to simulate virus spread on a global scale2. The model also captures biological aspects of SARS-CoV-2 transmission, clinical features (such as lethality for each age group analysed) and the timing of non-pharmaceutical containment measures, such as lockdowns. Methods that calibrate these models to both epidemiological and virus-sequencing data could improve their performance for 'now-casting' and forecasting viral spread, as well as for assessing the effects of policies in real time. To respond better to future pandemics, we must understand how the SARS-CoV-2 virus dispersed so rapidly. A model of COVID-19 spread sheds light on cryptic transmission, undetected by surveillance efforts, in early 2020. Modelling undetected cases of infection at the start of the pandemic. |
Author | Cauchemez, Simon Bosetti, Paolo |
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Cites_doi | 10.1016/j.cell.2020.04.021 10.1016/j.jocs.2010.07.002 10.1038/s41586-021-04130-w 10.1093/bioinformatics/bty407 10.1038/s41562-021-01079-8 10.1126/science.abf2946 |
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References | DavisJ. T.Nature202160012713210.1038/s41586-021-04130-w1:CAS:528:DC%2BB3MXisFyrsbfK346958378636257 BalcanD.J. Comput. Sci.201011321452141593910.1016/j.jocs.2010.07.0023056392 FauverJ. R.Cell20201819909963238654510.1016/j.cell.2020.04.0211:CAS:528:DC%2BB3cXhtVKmtrjE7204677 du PlessisL.Science20213717087123341993610.1126/science.abf29462021Sci...371..708D1:CAS:528:DC%2BB3MXktFOrtbY%3D CDC Stands Up New Disease Forecasting Center. https://www.cdc.gov/media/releases/2021/p0818-disease-forecasting-center.html (CDC, 2021). HaleT.Nature Hum. Behav.2021552953810.1038/s41562-021-01079-8 HadfieldJ.Bioinformatics201834412141232979093910.1093/bioinformatics/bty4071:CAS:528:DC%2BC1MXpsFens78%3D6247931 J. T. Davis (CM19807094_CR1) 2021; 600 J. R. Fauver (CM19807094_CR3) 2020; 181 J. Hadfield (CM19807094_CR7) 2018; 34 T. Hale (CM19807094_CR6) 2021; 5 D. Balcan (CM19807094_CR2) 2010; 1 L. du Plessis (CM19807094_CR4) 2021; 371 CM19807094_CR5 34695837 - Nature. 2021 Oct 25;:null |
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Title | A reconstruction of early cryptic COVID spread |
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