Heavy metal and mineral concentrations and their relationship to histopathological findings in the bowhead whale ( Balaena mysticetus)

• Published in: The Science of the total environment Vol. 399; no. 1; pp. 165 - 178
• Main Authors: Rosa, Cheryl, Blake, John E., Bratton, Gerald R., Dehn, Larissa-A., Gray, Matthew J., O'Hara, Todd M.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 25.07.2008; [Amsterdam; New York]: Elsevier Science; Elsevier Science
• Subjects: Age Factors; Alaska; Animal, plant and microbial ecology; Animals; Applied ecology; Arctic Regions; Aspartic acid; Balaena; Balaena mysticetus; bioaccumulation; Biological and medical sciences; Bowhead whale; Bowhead Whale - physiology; Cadmium; Cadmium - pharmacokinetics; Cadmium - toxicity; Climate change; Ecology; Ecotoxicology, biological effects of pollution; endangered species; Epidemiology; Fibromuscular Dysplasia - chemically induced; Fibromuscular Dysplasia - pathology; Fibrosis; Fibrosis - chemically induced; Fibrosis - pathology; food contamination; Fundamental and applied biological sciences. Psychology; General aspects; Health; Heavy metals; Histological Techniques; Histology; histopathology; human health; Industrial development; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidneys; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Lung - drug effects; Lung - metabolism; Lung - pathology; Lungs; Mammalia; Marine mammals; Metals, Heavy - pharmacokinetics; Metals, Heavy - toxicity; minerals; Minerals - pharmacokinetics; Minerals - toxicity; Racemization; Raw materials; Risk Assessment; Seasons; Sex; Silver; Tissue Distribution; Toxicology; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution; Water Pollutants, Chemical - pharmacokinetics; Water Pollutants, Chemical - toxicity; Whales; Alaska; Arctic region; Arctic Regions; PNW, USA, Alaska, Barrow; PN, Arctic; Balaena mysticetus; Cadmium; Toxicology; Histology; Bowhead whale; Marine mammals; Concentration measurement; Pollutant; Balaena mysticetus;Bowhead whale;Cadmium;Histology;Marine mammals;Toxicology; Vertebrata; Mammalia; Whale; Cetacea; Heavy metal
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2008.01.062

The bowhead whale ( Balaena mysticetus) is a species endangered over much of its range that is of great cultural significance and subsistence value to the Inuit of Northern Alaska. This species occupies subarctic and arctic regions presently undergoing significant ecological change and hydrocarbon development. Thus, understanding the health status of the Bering–Chukchi–Beaufort Sea (BCBS) stock of bowhead whales is of importance. In this study, we evaluated the concentrations of six essential and non-essential elements (Zn, tHg, Ag, Se, Cu and Cd) in liver and kidney of bowhead whales ( n = 64). These tissues were collected from the Inuit subsistence hunt in Barrow, Wainwright and Kaktovik, Alaska between 1983 and 2001. Reference ranges of these elements (including previously reported data from 1983–1997) were developed for this species as part of a health assessment effort, and interpreted using improved aging techniques (aspartic acid racemization and baleen isotopic 13C methods) to evaluate trends over time with increased statistical power. Interactions between element concentrations and age, sex and harvest season were assessed. Age was found to be of highest significance. Sex and harvest season did not effect the concentrations of these elements, with the exception of renal Se levels, which were significantly higher in fall seasons. In addition, histological evaluation of tissues from whales collected between 1998–2001 was performed. Associations between concentrations of Cd in kidney and liver and scored histopathological changes were evaluated. Liver Cd concentration was strongly associated with the degree of lung fibromuscular hyperplasia ( P = 0.001) and moderately associated with the degree of renal fibrosis ( P = 0.03). Renal Cd concentration influenced the degree of lung fibromuscular hyperplasia and renal fibrosis ( P = 0.01). A significant age effect was found for both pulmonary fibromuscular hyperplasia and renal fibrosis, indicating age may be a causative factor. Improvements in aging techniques and the addition of histological indices help clarify the relationships between elements and the influence of life history parameters on concentrations of these elements and potential impacts on health. These data provide essential baseline input useful for monitoring the effects of arctic ecosystem change as it relates to global climate change and industrial development, as well as help inform epidemiological studies examining the public health implications of heavy metals in subsistence foods.