Rosai-Dorfman Disease Complicated by Autoimmune Hemolytic Anemia in a Child: A Case Report and Review of the Literature

Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agen...

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Published inCase reports in oncology Vol. 11; no. 1; pp. 55 - 62
Main Authors Lardhi, Amer A., Al-Mutairi, Abdullah K., Al-Qahtani, Mohammed H., Al-Mutairi, Atheer K.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 19.01.2018
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Abstract Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agents including viruses have been implicated. We describe a 2-year-old female child who presented with fever, pallor, and generalized lymphadenopathy complicated by the development of autoimmune hemolytic anemia. A review of the literature of this condition is also provided.
AbstractList Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agents including viruses have been implicated. We describe a 2-year-old female child who presented with fever, pallor, and generalized lymphadenopathy complicated by the development of autoimmune hemolytic anemia. A review of the literature of this condition is also provided.
Author Al-Mutairi, Atheer K.
Al-Mutairi, Abdullah K.
Al-Qahtani, Mohammed H.
Lardhi, Amer A.
AuthorAffiliation King Fahad Hospital of the University, Faculty of Medicine, Imam Abdulrahman bin Faisal University, AL-Khobar, Saudi Arabia
AuthorAffiliation_xml – name: King Fahad Hospital of the University, Faculty of Medicine, Imam Abdulrahman bin Faisal University, AL-Khobar, Saudi Arabia
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Cites_doi 10.1136/jcp.2005.029850
10.1097/SCS.0b013e3181f403ad
10.1111/j.1365-2559.1994.tb00604.x
10.1046/j.1365-2133.2001.04325.x
10.4084/MJHID.2013.022
10.1007/BF02724322
10.1016/S0046-8177(00)80254-3
10.1093/infdis/166.2.291
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Issue 1
Keywords Massive lymphadenopathy
Sinus histiocytosis
Autoimmune hemolytic anemia
Herpes simplex virus
Rosai-Dorfman disease
Language English
License This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
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PublicationTitle Case reports in oncology
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Levine PH, Jahan N, Murari P, et al: Detection of human herpes virus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). J Infect Dis 1992; 166: 291–295.132186110.1093/infdis/166.2.291
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Lauwers GY, Perez-Atayde A, Dorfman RF, et al: The digestive system manifestations of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy): review of 11 cases. Hum Pathol 2000; 31: 380–385.1074668310.1016/S0046-8177(00)80254-3
Foucar E, Rosai J, Dorfman R: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 1990; 7: 19–73.2180012
Kruse AL, Gengler C, Grätz KW, et al: Extranodal manifestation of Rosai-Dorfman disease without involvement of lymph nodes. J Craniofac Surg 2010; 21: 1733–1736.2111941010.1097/SCS.0b013e3181f403ad
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StartPage 55
SubjectTerms Anemia
Autoimmune hemolytic anemia
Biopsy
Blood
Bone marrow
Case Report
Case reports
Hemoglobin
Herpes simplex virus
Herpes viruses
Immunoglobulins
Infections
Laboratories
Lymphatic system
Massive lymphadenopathy
Neutrophils
Patients
Pediatrics
Rosai-Dorfman disease
Sinus histiocytosis
Sinuses
Viral infections
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Title Rosai-Dorfman Disease Complicated by Autoimmune Hemolytic Anemia in a Child: A Case Report and Review of the Literature
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