Rosai-Dorfman Disease Complicated by Autoimmune Hemolytic Anemia in a Child: A Case Report and Review of the Literature

Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agen...

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Published inCase reports in oncology Vol. 11; no. 1; pp. 55 - 62
Main Authors Lardhi, Amer A., Al-Mutairi, Abdullah K., Al-Qahtani, Mohammed H., Al-Mutairi, Atheer K.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 19.01.2018
Karger Publishers
Subjects
Anemia
Autoimmune hemolytic anemia
Biopsy
Blood
Bone marrow
Case Report
Case reports
Hemoglobin
Herpes simplex virus
Herpes viruses
Immunoglobulins
Infections
Laboratories
Lymphatic system
Massive lymphadenopathy
Neutrophils
Patients
Pediatrics
Rosai-Dorfman disease
Sinus histiocytosis
Sinuses
Viral infections
Nigeria
Sudan
Massive lymphadenopathy
Sinus histiocytosis
Autoimmune hemolytic anemia
Herpes simplex virus
Rosai-Dorfman disease
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Summary:Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agents including viruses have been implicated. We describe a 2-year-old female child who presented with fever, pallor, and generalized lymphadenopathy complicated by the development of autoimmune hemolytic anemia. A review of the literature of this condition is also provided.
ISSN:1662-6575
1662-6575
DOI:10.1159/000485968