Extremely Rare Pulmonary Metastases of Skin Basal Cell Carcinoma: Report of Two Cases with Clinicopathological Features

• Published in: Biomedicines Vol. 11; no. 2; p. 283
• Main Authors: Wojtyś, Małgorzata Edyta, Kiełbowski, Kajetan, Kunc, Michał, Skrzyniarz, Seweryn Adam, Lisowski, Piotr, Becht, Rafał, Żukowska, Paulina, Ptaszyński, Konrad, Wójcik, Janusz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2023; MDPI
• Subjects: Basal cell carcinoma; Bcl-2 protein; Blood; Cancer therapies; Case Report; Disease; Histology; Hormones, Sex; Immunohistochemistry; Lungs; Metastases; Metastasis; metastasizing basal cell carcinoma; Patients; Progesterone; Progesterone receptors; pulmonary metastasis; pulmonary metastasizing basal cell carcinoma; Radiation therapy; Skin; Skin cancer; Stem cells; Thoracic surgery; Tumors; Vismodegib; Poland; pulmonary metastasizing basal cell carcinoma; basal cell carcinoma; metastasizing basal cell carcinoma; pulmonary metastasis
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11020283

Basal cell carcinoma (BCC) is the most frequent human skin cancer, but metastasizing BCC (MBCC) is extremely rare, developing in approximately 0.0028% to 0.55% of BCC patients. Herein, we report two cases of pulmonary MBCC. The first one developed in a 72-year-old male who underwent surgical resection due to multiple recurrences and adjuvant radiotherapy. Immunohistochemistry showed that neoplastic cells expressed Ber-EP4, CK5/6, p63, EMA (focally), BCL-2, and CD10, but were negative for CK7, CK20, S100, estrogen and progesterone receptors, and TTF-1. The second case is a 64-year-old female treated with vismodegib. Clinicopathological features and differential diagnoses are described.