Characterization and antibacterial properties of genipin-crosslinked chitosan/poly(ethylene glycol)/ZnO/Ag nanocomposites

• Published in: Carbohydrate polymers Vol. 89; no. 1; pp. 111 - 116
• Main Authors: Liu, Yangshuo, Kim, Hyung-Il
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 05.06.2012; Elsevier
• Subjects: Anti-Bacterial Agents - chemistry; Antibacterial activity; antibacterial properties; Applied sciences; Bacillus subtilis; Bacteria - growth & development; Bandages; Biological and medical sciences; Burns; Carbohydrates; Chitosan; Chitosan - chemistry; Composites; Dressings; Escherichia coli; ethylene glycol; Exact sciences and technology; films (materials); Forms of application and semi-finished materials; Guanylate cyclase; hydrocolloids; hydrogels; Iridoids - chemistry; Mechanical properties; Medical sciences; Microscopy, Electron, Scanning; Nanocomposites; Nanocomposites - chemistry; nanoparticles; nanosilver; pH effects; Physicochemical properties; Poly(ethylene glycol); Polyethylene glycol; Polyethylene Glycols - chemistry; Polymer industry, paints, wood; Pseudomonas aeruginosa; Scanning electron microscopy; Silver; Silver - chemistry; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology of polymers; Technology. Biomaterials. Equipments; Wound healing; X-Ray Diffraction; Zinc oxide; Zinc Oxide - chemistry; Silver; Zinc oxide; Antibacterial activity; Chitosan; Poly(ethylene glycol); Biological properties; Mixing; Aglycone; Ethylene oxide polymer; Dressing; Nanocomposite; Manufacturing; Mechanism of action; Growth from solution; Swelling; Mechanical properties; Crosslinking; Semiinterpenetrating polymer network; Experimental study; Metal particle; Hybrid composite; Bactericidal effect; Chitosan derivatives; Morphology; Oside polymer; Antibacterial agent
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2012.02.058

► GC/PEG/ZnO films were prepared by casting solution. ► Films showed the pH-sensitive swelling and the improved mechanical properties. ► The antimicrobial activity of films increased as the content of ZnO increased. ► The antibacterial activity was improved by doping ZnO with Ag nanoparticles. Novel nanocomposites consisting of genipin-crosslinked chitosan (GC), poly(ethylene glycol) (PEG), zinc oxide (ZnO), and silver (Ag) nanoparticles were prepared for biomedical applications as the wound-healing materials. Various amounts of ZnO and Ag nanoparticles were dispersed in the GC/PEG hydrogel matrix without severe aggregation. The effects of composition and ZnO nanoparticles on the physico-chemical properties of nanocomposite samples were evaluated by infrared analysis, X-ray diffraction, and scanning electron microscopy. GC/PEG/ZnO/Ag nanocomposite showed the pH-sensitive swelling behavior and the improved mechanical properties. The antibacterial activities of nanocomposite films were tested toward the bacterial species Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. GC/PEG/ZnO/Ag composite films had higher antibacterial activities than GC/PEG and GC/PEG/ZnO nanocomposite films. GC/PEG/ZnO/Ag composite films have potential application as wound and burn dressings.