Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease

• Published in: Nature communications Vol. 15; no. 1; pp. 4602 - 9
• Main Authors: Cagle, Jackson N., de Araujo, Tiberio, Johnson, Kara A., Yu, John, Fanty, Lauren, Sarmento, Filipe P., Little, Simon, Okun, Michael S., Wong, Joshua K., de Hemptinne, Coralie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1385/2640; 631/378/1385/519; 692/617/375/1718; 9/30; Aged; Circadian rhythm; Circadian Rhythm - physiology; Circadian rhythms; Deep Brain Stimulation; Electrical stimuli; Female; Frequencies; Globus pallidus; Globus Pallidus - physiopathology; Home environment; Humanities and Social Sciences; Humans; Levodopa; Levodopa - therapeutic use; Male; Middle Aged; Movement disorders; multidisciplinary; Neurodegenerative diseases; Night; Nighttime; Parkinson Disease - physiopathology; Parkinson's disease; Retrospective Studies; Science; Science (multidisciplinary); Solitary tract nucleus; Subthalamic nucleus; Subthalamic Nucleus - physiopathology
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-48732-0

Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson’s disease (PD), but only a few studies have focused on the globus pallidus internus (GPi). This retrospective study investigates GPi circadian rhythms in a large cohort of subjects with PD (130 recordings from 93 subjects) with GPi activity chronically recorded in their home environment. We found a significant change in GPi activity between daytime and nighttime in most subjects (82.4%), with a reduction in GPi activity at nighttime in 56.2% of recordings and an increase in activity in 26.2%. GPi activity in higher frequency bands ( > 20 Hz) was more likely to decrease at night and in patients taking extended-release levodopa medication. Our results suggest that circadian fluctuations in the GPi vary across individuals and that increased power at night might be due to the reemergence of pathological neural activity. These findings should be considered to ensure successful implementation of adaptive neurostimulation paradigms in the real-world. The authors found that GPi circadian rhythms varied across individuals, with neural activity mainly decreasing at night but sometimes increasing. GPi circadian rhythms were frequency band-dependent and were modulated by the use of extended-release levodopa medication at night.