The oral microbiome: diversity, biogeography and human health

• Published in: Nature reviews. Microbiology Vol. 22; no. 2; pp. 89 - 104
• Main Authors: Baker, Jonathon L., Mark Welch, Jessica L., Kauffman, Kathryn M., McLean, Jeffrey S., He, Xuesong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2024; Nature Publishing Group
• Subjects: 631/158/855; 631/326/2565/2134; Archaea; Bacteria; Bacteria - genetics; Biogeography; Biomedical and Life Sciences; Humans; Immune system; Infectious Diseases; Life Sciences; Medical Microbiology; Microbiology; Microbiomes; Microbiota; Microenvironments; Microorganisms; Mouth - microbiology; Oral cavity; Parasitology; Pathology; Review Article; Systemic diseases; Virology; Viruses
• ISSN: 1740-1526; 1740-1534; 1740-1534
• DOI: 10.1038/s41579-023-00963-6

The human oral microbiota is highly diverse and has a complex ecology, comprising bacteria, microeukaryotes, archaea and viruses. These communities have elaborate and highly structured biogeography that shapes metabolic exchange on a local scale and results from the diverse microenvironments present in the oral cavity. The oral microbiota also interfaces with the immune system of the human host and has an important role in not only the health of the oral cavity but also systemic health. In this Review, we highlight recent advances including novel insights into the biogeography of several oral niches at the species level, as well as the ecological role of candidate phyla radiation bacteria and non-bacterial members of the oral microbiome. In addition, we summarize the relationship between the oral microbiota and the pathology of oral diseases and systemic diseases. Together, these advances move the field towards a more holistic understanding of the oral microbiota and its role in health, which in turn opens the door to the study of novel preventive and therapeutic strategies. In this Review, He and co-workers explore the structure and diversity of the oral microbiota, and they discuss the role of the oral microbiota in the pathology of both oral and systemic diseases.