Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family

Solving the structure of Pla l 1 elucidated the preserved fold of Ole e 1-like proteins while IgE cross-reactivity in this family is limited to molecules with high sequence identity. Diagnostic accuracy using source-specific Ole e 1-like molecules is essential for discriminating plantain from other...

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Published inJournal of allergy and clinical immunology Vol. 140; no. 1; pp. 277 - 280
Main Authors Stemeseder, Teresa, MSc, Freier, Regina, PhD, Wildner, Sabrina, MSc, Fuchs, Julian E., PhD, Briza, Peter, PhD, Lang, Roland, PhD, Batanero, Eva, PhD, Lidholm, Jonas, PhD, Liedl, Klaus R., PhD, Campo, Paloma, MD, PhD, Hawranek, Thomas, MD, Villalba, Mayte, PhD, Brandstetter, Hans, PhD, Ferreira, Fatima, PhD, Gadermaier, Gabriele, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 01.07.2017
Subjects
Allergens
Allergies
Allergy and Immunology
Amino Acid Sequence
Antigens, Human Platelet - chemistry
Antigens, Human Platelet - immunology
Antigens, Plant - chemistry
Antigens, Plant - immunology
Cation exchange
Cation exchanging
Chemical bonds
Chemical Phenomena
Cross Reactions - immunology
Cross-reactivity
Crystal structure
Crystallography
Divergence
Fourier transforms
Humans
Immunoglobulin E
Immunology
Integrin beta3
Light scattering
Models, Molecular
Molecular Conformation
Phospholipase A
Photon correlation spectroscopy
Plant Proteins - chemistry
Plant Proteins - immunology
Pollen
Pollinosis
Proteins
Size exclusion chromatography
Strands
Structure-Activity Relationship
Zinc
Pla l 1
PR-10
DLS
IgE cross-reactivity
Dynamic light scattering
FTIR
crystal structure
plantain pollen allergy
Ole e 1-like proteins
Fourier transform infrared spectroscopy
Pathogenesis-related protein family PR-10
Enzyme-linked immunosorbent assay
ELISA
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Summary:Solving the structure of Pla l 1 elucidated the preserved fold of Ole e 1-like proteins while IgE cross-reactivity in this family is limited to molecules with high sequence identity. Diagnostic accuracy using source-specific Ole e 1-like molecules is essential for discriminating plantain from other pollen allergies.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
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ObjectType-Correspondence-1
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.10.035