Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications

Hodgkin lymphomas (HLs) are neoplasms of large B cells. Two types are recognized: nodular lymphocyte predominant HL (NLPHL) and classical HL (CHL). In both types, there may be morphological and possibly biological overlap with large B-cell lymphomas (LBCLs) of non-HL types. These include nodular scl...

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Bibliographic Details
Published inModern pathology Vol. 26; no. Suppl 1; pp. S57 - S70
Main Author Harris, Nancy L
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 2013
Elsevier Limited
Subjects
692/699/67/1990/291/1556
692/699/67/1990/291/1621/1915
692/700/139
Cells
Classification
Diagnosis, Differential
Hodgkin Disease - pathology
Humans
Immune system
Immunophenotyping
Laboratory Medicine
long-course-article
Lymphocytes
Lymphoma
Lymphoma, Large B-Cell, Diffuse - pathology
Medicine
Medicine & Public Health
Morphology
Pathology
Tumors
Young adults
United States > US
Massachusetts
classification
immunophenotype
lymphoma
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Summary:Hodgkin lymphomas (HLs) are neoplasms of large B cells. Two types are recognized: nodular lymphocyte predominant HL (NLPHL) and classical HL (CHL). In both types, there may be morphological and possibly biological overlap with large B-cell lymphomas (LBCLs) of non-HL types. These include nodular sclerosis CHL and primary mediastinal large B-cell lymphoma; CHL rich in lymphocytes and NLPHL; and NLPHL and T-cell/histiocyte-rich LBCL. This review covers the defining features of each of these diseases, the borderlines between them, and strategies for differential diagnosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2012.182