“Compression-Only” Behavior of Phospholipid-Coated Contrast Bubbles

Abstract Ultrasound contrast agents oscillate approximately linearly up to a certain pressure range where nonlinearity sets in. Nonlinear microbubble oscillations are exploited in ultrasound pulse-echo imaging as this improves the contrast-to-tissue ratio. Here we report the observation of a highly...

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Published inUltrasound in medicine & biology Vol. 33; no. 4; pp. 653 - 656
Main Authors de Jong, Nico, Emmer, Marcia, Chin, Chien Ting, Bouakaz, Ayache, Mastik, Frits, Lohse, Detlef, Versluis, Michel
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.04.2007
Subjects
Contrast Media
Humans
Microbubbles
Phospholipids
Radiology
Stress, Mechanical
Ultrasonography, Doppler, Pulsed - instrumentation
Ultrasonography, Doppler, Pulsed - methods
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Summary:Abstract Ultrasound contrast agents oscillate approximately linearly up to a certain pressure range where nonlinearity sets in. Nonlinear microbubble oscillations are exploited in ultrasound pulse-echo imaging as this improves the contrast-to-tissue ratio. Here we report the observation of a highly nonlinear response of phospholipid-coated contrast agents at pressures as low as 50 kPa, termed “compression-only” behavior, where the microbubbles only compress, yet hardly expand. Time-resolved bubble dynamics recorded through ultra high-speed imaging revealed that nearly 40% of the coated bubbles show “compression-only” behavior. (E-mail: n.dejong@erasmusmc.nl )
Bibliography:ObjectType-Article-1
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ISSN:0301-5629
1879-291X
DOI:10.1016/j.ultrasmedbio.2006.09.016