CD4 T Cell Count Reconstitution in HIV Controllers after Highly Active Antiretroviral Therapy

• Published in: Clinical infectious diseases Vol. 50; no. 8; pp. 1187 - 1191
• Main Authors: Okulicz, Jason F., Grandits, Greg A., Weintrob, Amy C., Landrum, Michael L., Ganesan, Anuradha, Crum-Cianflone, Nancy F., Agan, Brian K., Marconi, Vincent C.
• Format: Journal Article
• Language: English
• Published: Oxford The University of Chicago Press 15.04.2010; University of Chicago Press; Oxford University Press
• Subjects: Adult; AIDS; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral drugs; Antiretroviral Therapy, Highly Active; Antiviral agents; Biological and medical sciences; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - immunology; Drug therapy; Elites; Female; Highly active antiretroviral therapy; HIV; HIV Infections - drug therapy; HIV Infections - immunology; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Male; Medical sciences; Patients; Pharmacology. Drug treatments; Statistical significance; T cell receptors; T lymphocytes; United States; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Virology; Weighted averages; Young Adult; United States; United States > US; Immunopathology; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Numeration; Chemotherapy; Treatment; Immunological investigation; Viral disease; T-Lymphocyte; Antiviral; Human immunodeficiency virus
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/651421

Sixty-two human immunodeficiency virus (HIV) controllers (6 elite and 56 viremic controllers) in the US Military Department of Defense HIV Natural History Study cohort initiated highly active antiretroviral therapy (HAART) and achieved statistically significant mean CD4 cell count increases, although the gains were lower than those in treated noncontrollers. HIV controllers experienced CD4 cell count reconstitution with HAART regardless of pretherapy viral load, including patients with undetectable viral loads at HAART initiation.