Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands

Abstract Introduction A worldwide increasing incidence is seen for oesophageal adenocarcinoma, but not for oesophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma. Purposes of the current study were to evaluate the changing incidence rates of oesophageal and gastric cardia cancer...

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Published inEuropean journal of cancer (1990) Vol. 48; no. 11; pp. 1624 - 1632
Main Authors Dikken, Johan L, Lemmens, Valery E, Wouters, Michel W.J.M, Wijnhoven, Bas P, Siersema, Peter D, Nieuwenhuijzen, Grard A, van Sandick, Johanna W, Cats, Annemieke, Verheij, Marcel, Coebergh, Jan Willem, van de Velde, Cornelis J.H
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.07.2012
Elsevier
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Summary:Abstract Introduction A worldwide increasing incidence is seen for oesophageal adenocarcinoma, but not for oesophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma. Purposes of the current study were to evaluate the changing incidence rates of oesophageal and gastric cardia cancer, and to assess survival trends. Patients and methods Patients diagnosed with oesophageal adenocarcinoma ( N = 12,195) or SCC ( N = 9046), or gastric cardia adenocarcinoma ( N = 9900) between 1989 and 2008 in the Netherlands were included. Changes in European Standard Population (ESP) and relative survival over time were evaluated. Results Incidence rates for oesophageal adenocarcinoma increased in males (+7.5%, P < 0.001) and females (+5.2%, P < 0.001), while the incidence for oesophageal SCC remained stable in males (−0.2%, P = 0.6) and slightly increased in females (+1.7%, P = 0.001). The incidence for gastric cardia cancer decreased in males (−1.2%, P < 0.006), and remained stable in females (−0.2%, P = 0.7). Five-year survival for both M0 and M1 oesophageal carcinoma doubled over the last 20 years. No significant changes in survival were found for M0 and M1 gastric cardia carcinoma. Discussion In the Netherlands, a rising incidence is seen for oesophageal adenocarcinoma, but not for gastric cardia adenocarcinoma. This finding most likely reflects true changes in disease burden, rather than being the result of changes in diagnosis or classification. The increased survival for oesophageal carcinoma can be attributed to centralisation of surgery, and an increased use of multimodality therapy, factors hardly acknowledged for gastric cancer.
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ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2012.01.009