COVID-19 Adaptive Humoral Immunity Models: Weakly Neutralizing Versus Antibody-Disease Enhancement Scenarios

The interplay between the virus, infected cells and immune responses to SARS-CoV-2 is still under debate. By extending the basic model of viral dynamics, we propose here a formal approach to describe neutralisation versus weak (or non-)neutralisation scenarios and compare them with the possible effe...

Full description

Saved in:
Bibliographic Details
Published inActa biotheoretica Vol. 70; no. 4; p. 23
Main Authors Danchin, Antoine, Pagani-Azizi, Oriane, Turinici, Gabriel, Yahiaoui, Ghozlane
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.12.2022
Springer Nature B.V
Springer Verlag
Subjects
COVID-19
Education
Evolutionary Biology
Humoral immunity
Immune clearance
Immune response
Immunology
Life Sciences
Mathematics
Numerical Analysis
Philosophy
Philosophy of Biology
Regular
Regular Article
Severe acute respiratory syndrome coronavirus 2
Vaccination
COVID-19
Virus - immune system interaction
SARS-CoV-2
Virus model
Antibody disease enhancement
Non-neutralizing antibodies
Online AccessGet full text

Cover

More Information
Summary:The interplay between the virus, infected cells and immune responses to SARS-CoV-2 is still under debate. By extending the basic model of viral dynamics, we propose here a formal approach to describe neutralisation versus weak (or non-)neutralisation scenarios and compare them with the possible effects of antibody-dependent enhancement (ADE). The theoretical model is consistent with the data available in the literature; we show that both weakly neutralising antibodies and ADE can result in final viral clearance or disease progression, but that the immunodynamics are different in each case. As a significant proportion of the world’s population is already naturally immune or vaccinated, we also discuss the implications for secondary infections after vaccination or in the presence of immune system dysfunctions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0001-5342
1572-8358
DOI:10.1007/s10441-022-09447-1