Nonhuman primate models of human immunology

Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman pri...

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Bibliographic Details
Published inAntioxidants & redox signaling Vol. 14; no. 2; p. 261
Main Authors Messaoudi, Ilhem, Estep, Ryan, Robinson, Bridget, Wong, Scott W
Format Journal Article
LanguageEnglish
Published United States 15.01.2011
Subjects
Animals
Dendritic Cells - immunology
Humans
Immune System - immunology
Killer Cells, Natural - immunology
Macaca mulatta - immunology
Models, Animal
Models, Immunological
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Summary:Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system.
ISSN:1557-7716
DOI:10.1089/ars.2010.3241