Proteomics in Neuroscience: From Protein to Network

Proteomic tools offer a new platform for studies of complex biological functions involving large numbers and networks of proteins. Intracellular networks of proteins perform key functions in neurons and glia. The unicellular eukaryote Saccharomyces cerevisiae has been the prototype for eukaryotic pr...

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Bibliographic Details
Published inThe Journal of neuroscience Vol. 21; no. 21; pp. 8315 - 8318
Main Authors Grant, Seth G. N, Blackstock, Walter P
Format Journal Article
LanguageEnglish
Published United States Soc Neuroscience 01.11.2001
Society for Neuroscience
Subjects
Animals
Cell Communication
Computational Biology
Gene Expression
Humans
Macromolecular Substances
Mass Spectrometry
Mini-Reviews
Neuroglia - metabolism
Neurons - metabolism
Neurosciences - methods
Protein Binding - physiology
Proteins - genetics
Proteins - metabolism
Proteome - metabolism
Saccharomyces cerevisiae
Signal Transduction - physiology
Two-Hybrid System Techniques
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Summary:Proteomic tools offer a new platform for studies of complex biological functions involving large numbers and networks of proteins. Intracellular networks of proteins perform key functions in neurons and glia. The unicellular eukaryote Saccharomyces cerevisiae has been the prototype for eukaryotic proteomic studies, and when combined with genomics, microarrays, genetics, and pharmacology, new insights into the integrated function of the cell emerge. The anatomical complexity of the nervous system both in cell types and in the vast number of synapses introduces novel technical and biological issues regarding the subcellular organization of protein networks. Here we will discuss the technology of proteomics and its applications to the nervous system.
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ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.21-21-08315.2001