Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, w...

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Published inAging and disease Vol. 11; no. 1; pp. 129 - 140
Main Authors Xia, Shijin, Zhou, Changxi, Kalionis, Bill, Shuang, Xiaoping, Ge, Haiyan, Gao, Wen
Format Journal Article
LanguageEnglish
Published United States JKL International 01.02.2020
JKL International LLC
Subjects
Antioxidants (Nutrients)
China
Chronic obstructive lung disease
Development and progression
Diseases
Displays (Marketing)
Elderly patients
Gerontology
Homeostasis
Inflammation
Lung diseases
Morbidity
Mortality
Oxidation-reduction reactions
Oxidative stress
Respiratory tract diseases
Review
Stem cells
China
inflammaging
oxidative stress
chronic obstructive pulmonary disease
lung mesenchymal stem cells
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Summary:Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, which are closely related to chronic inflammatory response and oxidation-antioxidant imbalance in the pathogenesis of COPD. COPD displays distinct inflammaging features, including increased cellular senescence and oxidative stress, stem cell exhaustion, alterations in the extracellular matrix, reduced levels of endogenous anti-inflammaging molecules, and reduced autophagy. Given that COPD and inflammaging share similar general features, it is very important to identify the specific mechanisms of inflammaging, which involve oxidative stress, inflammation and lung mesenchymal stem cell function in the development of COPD, especially in elderly COPD patients. In this review, we highlight the studies relevant to COPD progression, and focus on mechanisms associated with inflammaging.
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These authors contributed equally to this work.
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2019.0508