Host glycolipids in SARS-CoV-2 entry

• Published in: Nature chemical biology Vol. 18; no. 1; pp. 6 - 7
• Main Authors: Uraki, Ryuta, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2022; Nature Publishing Group
• Subjects: 631/326/596/4130; 631/92/221; 692/699/255; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Cell Biology; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; COVID-19; Glycolipids; Humans; News & Views; news-and-views; Polysaccharides; Protein Binding; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike protein; Virus Internalization

A new study demonstrates that the receptor-binding domain of the SARS-CoV-2 spike protein binds to sialylated glycans, especially glycolipids, to facilitate viral entry, an insight that identifies new potential targets for SARS-CoV-2 interventions.