Host glycolipids in SARS-CoV-2 entry

A new study demonstrates that the receptor-binding domain of the SARS-CoV-2 spike protein binds to sialylated glycans, especially glycolipids, to facilitate viral entry, an insight that identifies new potential targets for SARS-CoV-2 interventions.

Saved in:
Bibliographic Details
Published inNature chemical biology Vol. 18; no. 1; pp. 6 - 7
Main Authors Uraki, Ryuta, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2022
Nature Publishing Group
Subjects
631/326/596/4130
631/92/221
692/699/255
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
COVID-19
Glycolipids
Humans
News & Views
news-and-views
Polysaccharides
Protein Binding
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Spike protein
Virus Internalization
Online AccessGet full text

Cover

More Information
Summary:A new study demonstrates that the receptor-binding domain of the SARS-CoV-2 spike protein binds to sialylated glycans, especially glycolipids, to facilitate viral entry, an insight that identifies new potential targets for SARS-CoV-2 interventions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Commentary-3
content type line 23
ISSN:1552-4450
1552-4469
1552-4469
DOI:10.1038/s41589-021-00923-2