Host glycolipids in SARS-CoV-2 entry

A new study demonstrates that the receptor-binding domain of the SARS-CoV-2 spike protein binds to sialylated glycans, especially glycolipids, to facilitate viral entry, an insight that identifies new potential targets for SARS-CoV-2 interventions.

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Published inNature chemical biology Vol. 18; no. 1; pp. 6 - 7
Main Authors Uraki, Ryuta, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2022
Nature Publishing Group
Subjects
631/326/596/4130
631/92/221
692/699/255
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
COVID-19
Glycolipids
Humans
News & Views
news-and-views
Polysaccharides
Protein Binding
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Spike protein
Virus Internalization
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Abstract A new study demonstrates that the receptor-binding domain of the SARS-CoV-2 spike protein binds to sialylated glycans, especially glycolipids, to facilitate viral entry, an insight that identifies new potential targets for SARS-CoV-2 interventions.
AbstractList A new study demonstrates that the receptor-binding domain of the SARS-CoV-2 spike protein binds to sialylated glycans, especially glycolipids, to facilitate viral entry, an insight that identifies new potential targets for SARS-CoV-2 interventions.
Author Uraki, Ryuta
Kawaoka, Yoshihiro
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  orcidid: 0000-0003-0890-1922
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  surname: Kawaoka
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  organization: The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Division of Virology, The Institute of Medical Science, The University of Tokyo, Department of Special Pathogens, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34754100$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1177_00375497231176085
crossref_primary_10_1021_acs_analchem_4c05966
crossref_primary_10_3390_pharmaceutics15010225
crossref_primary_10_3390_v15020464
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Cites_doi 10.1016/j.cell.2020.02.052
10.1126/science.abd2985
10.1038/ni.f.203
10.1016/j.cell.2020.09.033
10.26508/lsa.202000786
10.1038/s41589-021-00924-1
10.1016/j.celrep.2021.109364
10.1126/science.abd3072
10.1021/ac3023857
10.1038/s41594-019-0233-y
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631/92/221
692/699/255
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
COVID-19
Glycolipids
Humans
News & Views
news-and-views
Polysaccharides
Protein Binding
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Spike protein
Virus Internalization
Title Host glycolipids in SARS-CoV-2 entry
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