Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09

We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. I...

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Published inEmerging infectious diseases Vol. 30; no. 1; pp. 168 - 171
Main Authors Daulagala, Pavithra, Cheng, Samuel M.S., Chin, Alex, Luk, Leo L.H., Leung, Kathy, Wu, Joseph T., Poon, Leo L.M., Peiris, Malik, Yen, Hui-Ling
Format Journal Article
LanguageEnglish
Published United States Centers for Disease Control and Prevention 01.01.2024
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Abstract We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.
AbstractList We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.
We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.
Author Luk, Leo L.H.
Daulagala, Pavithra
Leung, Kathy
Yen, Hui-Ling
Peiris, Malik
Wu, Joseph T.
Chin, Alex
Poon, Leo L.M.
Cheng, Samuel M.S.
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Keywords clade 2.3.4.4.b
influenza
influenza A(H5N1)
viruses
cross-reactive antibody response
pandemic risk assessment
neuraminidase inhibition antibody
respiratory infections
influenza A(H1N1)pdm09
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Snippet We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from...
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StartPage 168
SubjectTerms Adult
Animals
Antibodies
Antibodies, Viral
Avian flu
Birds
Blood & organ donations
clade 2.3.4.4.b
Dispatch
Health care
Humans
Infections
influenza
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H5N1 Subtype
influenza A(H1N1)pdm09
influenza A(H5N1)
Influenza in Birds
Influenza Vaccines
Influenza, Human
Neuraminidase
Pandemics
Proteins
respiratory infections
Risk assessment
Surveillance
Vaccines
Viruses
Zoonoses
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Title Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
URI https://www.ncbi.nlm.nih.gov/pubmed/38147510
https://www.proquest.com/docview/2923629030
https://www.proquest.com/docview/2906772632
https://pubmed.ncbi.nlm.nih.gov/PMC10756388
https://doaj.org/article/a72c7cec56dd41599787dc44075533d5
Volume 30
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