Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09

• Published in: Emerging infectious diseases Vol. 30; no. 1; pp. 168 - 171
• Main Authors: Daulagala, Pavithra, Cheng, Samuel M.S., Chin, Alex, Luk, Leo L.H., Leung, Kathy, Wu, Joseph T., Poon, Leo L.M., Peiris, Malik, Yen, Hui-Ling
• Format: Journal Article
• Language: English
• Published: United States Centers for Disease Control and Prevention 01.01.2024
• Subjects: Adult; Animals; Antibodies; Antibodies, Viral; Avian flu; Birds; Blood & organ donations; clade 2.3.4.4.b; Dispatch; Health care; Humans; Infections; influenza; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; influenza A(H1N1)pdm09; influenza A(H5N1); Influenza in Birds; Influenza Vaccines; Influenza, Human; Neuraminidase; Pandemics; Proteins; respiratory infections; Risk assessment; Surveillance; Vaccines; Viruses; Zoonoses; Hong Kong China; California; United States > US; China; Europe; clade 2.3.4.4.b; influenza; influenza A(H5N1); viruses; cross-reactive antibody response; pandemic risk assessment; neuraminidase inhibition antibody; respiratory infections; influenza A(H1N1)pdm09
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid3001.230756

We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.