High fat diet causes rebound weight gain

Abstract Obesity is at epidemic proportions but treatment options remain limited. Treatment of obesity by calorie restriction (CR) despite having initial success often fails due to rebound weight gain. One possibility is that this reflects an increased body weight (BW) set-point. Indeed, high fat di...

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Bibliographic Details
Published inMolecular metabolism (Germany) Vol. 2; no. 2; pp. 103 - 108
Main Authors McNay, David E.G, Speakman, John R
Format Journal Article
LanguageEnglish
Published Germany Elsevier GmbH 01.04.2013
Elsevier
Subjects
Brief Communication
Calorie restriction
Endocrinology & Metabolism
Hypothalamus
Neurogenesis
Obesity
Rebound weight gain
Obesity
Hypothalamus
Neurogenesis
Rebound weight gain
Calorie restriction
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Summary:Abstract Obesity is at epidemic proportions but treatment options remain limited. Treatment of obesity by calorie restriction (CR) despite having initial success often fails due to rebound weight gain. One possibility is that this reflects an increased body weight (BW) set-point. Indeed, high fat diets (HFD) reduce adult neurogenesis altering hypothalamic neuroarchitecture. However, it is uncertain if these changes are associated with weight rebound or if long-term weight management is associated with reversing this. Here we show that obese mice have an increased BW set-point and lowering this set-point is associated with rescuing hypothalamic remodelling. Treating obesity by CR using HFD causes weight loss, but not rescued remodelling resulting in rebound weight gain. However, treating obesity by CR using non-HFD causes weight loss, rescued remodelling and attenuates rebound weight gain. We propose that these phenomena may explain why successful short-term weight loss improves obesity in some people but not in others.
ISSN:2212-8778
2212-8778
DOI:10.1016/j.molmet.2012.10.003