A prospective cohort study on the association between dietary fatty acids intake and risk of hypertension incident

• Published in: Scientific reports Vol. 13; no. 1; p. 21112
• Main Authors: Shakiba, Ebrahim, Najafi, Farid, Pasdar, Yahya, Moradinazar, Mehdi, Navabi, Jafar, Shakiba, Mohammad Hossein, Bagheri, Amir
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/75; 692/700/2814; Blood pressure; Cohort analysis; Dietary Fats - adverse effects; Dietary intake; Fatty acids; Fatty Acids - adverse effects; Fatty Acids, Monounsaturated - adverse effects; Humanities and Social Sciences; Humans; Hypertension; Hypertension - epidemiology; Hypertension - etiology; multidisciplinary; Polyunsaturated fatty acids; Prospective Studies; Science; Science (multidisciplinary); Trans Fatty Acids - adverse effects
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-48256-5

There are inconclusive results available on the association between dietary fatty acid intake and the risk of hypertension (HTN) incident. In this study, we investigate the relationship between baseline dietary fatty acids intake including polyunsaturated fatty acid (PUFA), trans fatty acids (TFA), monounsaturated fatty acid (MUFA), and saturated fatty acid (SFA), and the risk of first incidence hypertension. The current prospective cohort study was carried out from the Ravansar Non-Communicable Diseases (RaNCD) cohort. A food frequency questionnaire (FFQ) with 118 items was used for the assessment of dietary data. Cox proportional hazards analyses were done to estimate hazard ratios (HR) and 95% confidence intervals (CIs) of the highest versus lowest quartile intake of SFA, PUFA, MUFA, and SFA and risk of HTN. Out of 7359 eligible participants, 597 new cases of HTN were identified over an average of 6.4 ± 1.33 years of follow-up. No significant relationship was observed between the fourth compared to the first categories of dietary SFA (HR: 0.82, 95% CI 0.55, 1.21; P trend: 0.476), MUFA (HR: 0.71, 95% CI 0.48, 1.06; P trend: 0.252), PUFA (HR: 0.86, 95% CI 0.62, 1.19; P trend: 0.315) and TFA (HR: 0.99, 95% CI 0.76, 1.27; P trend: 0.675), and risk of HTN. However, a significant inverse association between each 1 g per day increase in dietary MUFA intake during 6.4 years of follow up and HTN incident (HR: 0.97; 95% CI 0.94, 0.99; P 0.044) was observed. In brief, our study revealed that higher dietary MUFA intake was protectively associated with HTN incident. Dietary MUFA-rich foods should be encouraged to improve blood pressure.