Preparation of pH- and ionic-strength responsive biodegradable fumaric acid crosslinked carboxymethyl cellulose

• Published in: Carbohydrate polymers Vol. 90; no. 4; pp. 1634 - 1641
• Main Authors: Akar, Emine, Altınışık, Aylin, Seki, Yoldaş
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 06.11.2012; Elsevier
• Subjects: aluminum; Applied sciences; atomic force microscopy; Biodegradability; biodegradation; Calorimetry, Differential Scanning; Carboxymethylcellulose; Carboxymethylcellulose Sodium - chemistry; Carboxymethylcellulose Sodium - metabolism; Cellulose and derivatives; Cross-Linking Reagents - metabolism; crosslinking; differential scanning calorimetry; endo-1,4-beta-glucanase; Exact sciences and technology; Fourier transform infrared spectroscopy; Fumarates - metabolism; Fumaric acid; half life; hydrocolloids; Hydrogel; Hydrogels - chemical synthesis; Hydrogen-Ion Concentration; ionic strength; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Natural polymers; Osmolar Concentration; pH-responsive; Physicochemistry of polymers; roughness; scanning electron microscopy; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; X-Ray Diffraction; Hydrogel; Fumaric acid; Carboxymethylcellulose; Biodegradability; pH-responsive; Biological properties; Stoichiometry; Property processing relationship; Thermal stability; Colloidal gel; pH; Cellulose ether; Cellulose(carboxymethyl); Swelling; Crosslinking; Crystallinity; Experimental study; Polyelectrolyte; Structure processing relationship; Salt effect; Ionic strength; Morphology; Preparation; Enzymatic digestion; Kinetics
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2012.07.043

► A novel biodegradable sodium carboxymethyl cellulose-based hydrogel was synthesized by using fumaric acid (FA) as a crosslinking agent. ► Hydrogels show pH- and ionic-strength responsive behavior. ► Reversible pH-responsiveness of hydrogels was observed. ► Hydrogels exhibited biodegradable property. A novel biodegradable sodium carboxymethyl cellulose (NaCMC)-based hydrogel was synthesized by using fumaric acid (FA) as a crosslinking agent at various ratios. Hydrogels (CMCF) were characterized using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), and atomic force microscopy (AFM). Swelling behaviors of hydrogels were investigated in distilled water, various salt, and pH solutions. The FTIR results indicated the crosslinking between carboxyl groups of FA with hydroxyl group of NaCMC through ester formation. AFM analyses showed that roughness of hydrogel surface decreased with increasing crosslinker concentration. The swelling capacity decreased with an increase in charge of the metal cation (Al3+<Ca2+<Na+). In order to investigate reversible pH sensitivity of CMCF hydrogels, pH-dependent swelling was studied at pH 2 and 10. Reversible pH-responsiveness of CMCF hydrogels was achieved. CMCF hydrogels containing the greatest ratio of FA exhibited the longest biodegradation time with a half life of 21h using cellulase.