Effect of human leukocyte antigen class II genes on insulin deficiency in slow-onset type 1 diabetes in the Japanese population

Abstract The aim of this study is to determine the contribution of human leukocyte antigen (HLA) class II genes to insulin deficiency in slow-onset type 1 diabetes (T1D). Our results suggest that the susceptibility conferred by HLA subtypes to slow-onset T1D differs between insulin-deficient patient...

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Published inDiabetes research and clinical practice Vol. 93; no. 1; pp. e33 - e36
Main Authors Katahira, Masahito, Hanakita, Mizuki, Yasuda, Yoshinori, Maeda, Harumi, Ito, Tatsuo, Segawa, Satoko
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.07.2011
Subjects
Adolescent
Adult
Age of Onset
Aged
Asian Continental Ancestry Group
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - metabolism
Endocrinology & Metabolism
Ethnic differences
Female
Genetic Predisposition to Disease - genetics
Haplotypes
Histocompatibility Antigens Class II - genetics
HLA-DQ Antigens - genetics
HLA-DR Antigens - genetics
Human leukocyte antigen (HLA)
Humans
Insulin - deficiency
Latent autoimmune diabetes in adults (LADA)
Male
Middle Aged
Type 1 diabetes
Young Adult
Human leukocyte antigen (HLA)
Insulin deficiency
Ethnic differences
Type 1 diabetes
Latent autoimmune diabetes in adults (LADA)
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Summary:Abstract The aim of this study is to determine the contribution of human leukocyte antigen (HLA) class II genes to insulin deficiency in slow-onset type 1 diabetes (T1D). Our results suggest that the susceptibility conferred by HLA subtypes to slow-onset T1D differs between insulin-deficient patients and non-insulin-deficient patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2011.03.025