A promising vaccine candidate against COVID-19

Elevated T cell responses were also found in the mice vaccinated with the S-RBD vaccine. [...]the authors further evaluated the involvement of cellular immune response in the prevention of SARS-CoV-2 infection [5]. Interestingly, adoptive transferring the sera obtained from vaccinated mice effective...

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Bibliographic Details
Published inMolecular biomedicine Vol. 1; no. 1; p. 8
Main Authors Wang, Xiwei, Tu, Wenwei
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 30.09.2020
Springer Nature B.V
Springer
Subjects
Aluminum
Antibodies
Antigens
Binding sites
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Coronaviruses
COVID-19
COVID-19 vaccines
Disease transmission
Enzymes
Immunology
Infections
Lymphocytes
Molecular Medicine
Pandemics
Primates
Proteins
Research Highlight
Severe acute respiratory syndrome coronavirus 2
Hong Kong China
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Summary:Elevated T cell responses were also found in the mice vaccinated with the S-RBD vaccine. [...]the authors further evaluated the involvement of cellular immune response in the prevention of SARS-CoV-2 infection [5]. Interestingly, adoptive transferring the sera obtained from vaccinated mice effectively protected the recipient mice from live SARS-CoV-2 infection, while the splenic T cells from same vaccinated mice did not show similar protective effect. [...]the protection was mainly mediated by the specific humoral responses induced by the S-RBD vaccine. [...]the authors determined the safety profile of the S-RBD vaccine [5].
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2662-8651
2662-8651
DOI:10.1186/s43556-020-00008-x