Early changes of pulmonary arterial hemodynamics in patients with systemic sclerosis: flow pattern, WSS, and OSI analysis with 4D flow MRI

• Published in: European radiology Vol. 31; no. 6; pp. 4253 - 4263
• Main Authors: Ikoma, Takenori, Suwa, Kenichiro, Sano, Makoto, Ushio, Takasuke, Saotome, Masao, Ogawa, Noriyoshi, Satoh, Hiroshi, Maekawa, Yuichiro
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2021; Springer Nature B.V
• Subjects: Blood flow; Catheterization; Change detection; Data analysis; Diagnostic Radiology; Diastole; Flow distribution; Flow velocity; Fluid dynamics; Fluid flow; Hemodynamics; Hypertension; Imaging; Internal Medicine; Interventional Radiology; Magnetic Resonance; Magnetic resonance imaging; Medicine; Medicine & Public Health; Minimum flow; Neuroradiology; Pattern analysis; Pulmonary arteries; Pulmonary artery; Radiology; Reynolds number; Scleroderma; Shear stress; Systemic sclerosis; Systole; Three dimensional flow; Ultrasound; Wall shear stresses; Hemodynamics; Magnetic resonance imaging; Blood flow velocity; Systemic sclerosis; Pulmonary artery
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-020-07301-x

Objectives To study the pulmonary artery (PA) hemodynamics in patients with systemic sclerosis (SSc) using 4D flow MRI (4D-flow). Methods Twenty-three patients with SSc (M/F: 2/21, 57 ± 15 years, 3 manifest PA hypertension (PAH) by right heart catheterization) and 10 control subjects (M/F: 1/9, 55 ± 17 years) underwent 4D-flow for the in vivo measurement of 3D blood flow velocities in the PA. Data analysis included area-averaged flow quantification at the main PA, 3D wall shear stress (WSS), oscillatory shear index (OSI) calculation along the PA surface, and Reynolds number. The composite outcome of all-cause death and major adverse cardiac events was also investigated. Results The maximum PA flow at the systole did not differ, but the minimum flow at the diastole was significantly greater in patients with SSc compared with that in control subjects (7.7 ± 16.0 ml/s vs. ‑ 13.0 ± 17.3 ml/s, p  < 0.01). The maximum WSS at the peak systole was significantly lower and OSI was significantly greater in patients with SSc compared with those in control subjects (maximum WSS: 1.04 ± 0.20 Pa vs. 1.33 ± 0.34 Pa, p  < 0.01, OSI: 0.139 ± 0.031 vs. 0.101 ± 0.037, p  < 0.01). The cumulative event-free rate for the composite event was significantly lower in patients with minimum flow in main PA ≤ 9.22 ml/s ( p  = 0.012) and in patients with Reynolds number ≤ 2560 ( p  < 0.001). Conclusions 4D-flow has the potential to detect changes of PA hemodynamics noninvasively and predict the outcome in patients with SSc at the stage before manifest PAH. Key Points • The WSS at the peak systolic phase was significantly lower (p < 0.05), whereas OSI was greater (p < 0.01) in patients with SSc without manifest PAH than in controls. • The hemodynamic change detected by 4D-flow may help patient management even at the stage before manifest PAH in SSc. • The minimum PA flow and Reynolds number by 4D-flow will serve as a predictive marker for SSc.