A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24–36 weeks of gestation

• Published in: Diabetes research and clinical practice Vol. 89; no. 3; pp. 231 - 238
• Main Authors: Karacay, Özlem, Sepici-Dincel, Aylin, Karcaaltincaba, Deniz, Sahin, Duygu, Yalvaç, Serdar, Akyol, Mesut, Kandemir, Ömer, Altan, Nilgün
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.09.2010
• Subjects: Advanced oxidation protein product; Antioxidant status; Antioxidants - metabolism; Diabetes, Gestational - blood; Diabetes, Gestational - metabolism; Endocrinology & Metabolism; Female; Gestational Age; Gestational diabetes mellitus; Humans; Lipid peroxidation products; Lipid Peroxides - blood; Malondialdehyde - blood; Myeloperoxidase; Oxidative Stress - physiology; Peroxidase - blood; Pre-Eclampsia - blood; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Gestational diabetes mellitus; Lipid peroxidation products; Antioxidant status; Myeloperoxidase; Advanced oxidation protein product; Preeclampsia
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2010.04.015

Abstract Objective To assess the plasma and serum maternal total antioxidant status, circulating levels of lipid peroxidation breakdown products (MDA), protein oxidation markers (AOPPs), myeloperoxidase (MPO) and lipid hydroperoxide (LHP) in preeclampsia, gestational diabetes mellitus (GDM) patients and compare them with noncomplicated normal pregnancies between 24 and 36 weeks of gestation. Study design 27 GDM, 27 preeclampsia and 29 noncomplicated singleton pregnancies were included. The blood samples were taken at the diagnosis of disease. Results TAS was decreased in GDM and preeclampsia when compared to normal pregnancies. MDA levels were higher only in GDM group than normal pregnancies. AOPP levels were increased but MPO and LHP levels were not changed both in GDM and preeclampsia when compared to normal pregnancies. Conclusions We concluded that increased oxidative stress and reduction in antioxidant defense mechanisms may contribute to disease processes both in GDM and preeclampsia.