A Review of N-(1,3-Dimethylbutyl)-N′-phenyl-p-Phenylenediamine (6PPD) and Its Derivative 6PPD-Quinone in the Environment

• Published in: Toxics (Basel) Vol. 12; no. 6; p. 394
• Main Authors: Li, Yi, Zeng, Jingjing, Liang, Yongjin, Zhao, Yanlong, Zhang, Shujun, Chen, Zhongyan, Zhang, Jiawen, Shen, Xingze, Wang, Jiabin, Zhang, Ying, Sun, Yuxin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.05.2024; MDPI
• Subjects: 6PPD; 6PPD-quinone; Bioaccumulation; Biological magnification; Biota; Contaminants; Dormitories; Drinking water; Dust; Electronic waste; environmental distribution; Genetic transformation; Health risk assessment; Health risks; Neurotoxicity; Organisms; Phenylenediamine; Quinones; Roads & highways; Rubber; Runoff; Shopping centers; Teratogenicity; Tires; Toxicity; China; Japan; Germany; toxicity; environmental distribution; 6PPD-quinone; 6PPD
• ISSN: 2305-6304; 2305-6304
• DOI: 10.3390/toxics12060394

As an antioxidant and antiozonant, N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is predominantly used in the rubber industry to prevent degradation. However, 6PPD can be ozonated to generate a highly toxic transformation product called N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-quinone), which is toxic to aquatic and terrestrial organisms. Thus, 6PPD and 6PPD-quinone, two emerging contaminants, have attracted extensive attention recently. This review discussed the levels and distribution of 6PPD and 6PPD-quinone in the environment and investigated their toxic effects on a series of organisms. 6PPD and 6PPD-quinone have been widely found in air, water, and dust, while data on soil, sediment, and biota are scarce. 6PPD-quinone can cause teratogenic, developmental, reproductive, neuronal, and genetic toxicity for organisms, at environmentally relevant concentrations. Future research should pay more attention to the bioaccumulation, biomagnification, transformation, and toxic mechanisms of 6PPD and 6PPD-quinone.