Manifestations of early brain recovery associated with abstinence from alcoholism

• Published in: Brain (London, England : 1878) Vol. 130; no. 1; pp. 36 - 47
• Main Authors: Bartsch, Andreas J., Homola, György, Biller, Armin, Smith, Stephen M., Weijers, Heinz-Gerd, Wiesbeck, Gerhard A., Jenkinson, Mark, Stefano, Nicola De, Solymosi, László, Bendszus, Martin
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2007; Oxford Publishing Limited (England)
• Subjects: Adult; alcoholism; Alcoholism - metabolism; Alcoholism - pathology; Alcoholism - psychology; Aspartic Acid - analogs & derivatives; Aspartic Acid - analysis; Atrophy; Attention; Biological and medical sciences; Brain - metabolism; Brain - pathology; Brain Chemistry - physiology; Cerebellum - metabolism; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Choline - analysis; Creatine - analysis; Female; Fundamental and applied biological sciences. Psychology; Human viral diseases; Humans; Infectious diseases; Magnetic Resonance Spectroscopy - methods; Male; Medical sciences; Middle Aged; morphometry; MR spectroscopy; Neurology; Neuropsychological Tests; Prospective Studies; SIENA; Temperance; Vertebrates: nervous system and sense organs; Viral diseases; Viral diseases of the nervous system; voxelwise SIENA statistics; SIENA; morphometry; alcoholism; voxelwise SIENA statistics; MR spectroscopy; Nervous system diseases; Alcoholism; Central nervous system; NMR spectrometry; Morphometry; Recovery; Abstinence; Encephalon
• ISSN: 0006-8950; 1460-2156
• DOI: 10.1093/brain/awl303

Chronic alcohol abuse results in morphological, metabolic, and functional brain damage which may, to some extent, be reversible with early effects upon abstinence. Although morphometric, spectroscopic, and neuropsychological indicators of cerebral regeneration have been described previously, the overall amount and spatial preference of early brain recovery attained by abstinence and its associations with other indicators of regeneration are not well established. We investigated global and local brain volume changes in a longitudinal two-timepoint study with T1-weighted MRI at admission and after short-term (6–7 weeks) sobriety follow-up in 15 uncomplicated, recently detoxified alcoholics. Volumetric brain gain was related to metabolic and neuropsychological recovery. On admission and after short-term abstinence, structural image evaluation using normalization of atrophy (SIENA), its voxelwise statistical extension to multiple subjects, proton MR spectroscopy (1H-MRS), and neuropsychological tests were applied. Upon short-term sobriety, 1H-MRS levels of cerebellar choline and frontomesial N-acetylaspartate (NAA) were significantly augmented. Automatically detected global brain volume gain amounted to nearly two per cent on average and was spatially significant around the superior vermis, perimesencephalic, periventricular and frontal brain edges. It correlated positively with the percentages of cerebellar and frontomesial choline increase, as detected by 1H-MRS. Moreover, frontomesial NAA gains were associated with improved performance on the d2-test of attention. In 10 age- and gender-matched healthy control subjects, no significant brain volume or metabolite changes were observed. Although cerebral osmotic regulations may occur initially upon sobriety, significant increases of cerebellar choline and frontomesial NAA levels detected at stable brain water integrals and creatine concentrations, serum electrolytes and red blood cell indices in our patient sample suggest that early brain recovery through abstinence does not simply reflect rehydration. Instead, even the adult human brain and particularly its white matter seems to possess genuine capabilities for regrowth. Our findings emphasize metabolic as well as regionally distinct morphological capacities for partial brain recovery from toxic insults of chronic alcoholism and substantiate early measurable benefits of therapeutic sobriety. Further understanding of the precise mechanisms of this recovery may become a valuable model of brain regeneration with relevance for other disorders.