Pregnancy Outcomes in the Era of Universal Antiretroviral Treatment in Sub-Saharan Africa (POISE Study)

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 80; no. 1; p. 7
• Main Authors: Dadabhai, Sufia, Gadama, Luis, Chamanga, Rachel, Kawalazira, Rachel, Katumbi, Chaplain, Makanani, Bonus, Dula, Dingase, Hua, Nan, Lau, Bryan, Mallewa, Macpherson, Taha, Taha E
• Format: Journal Article
• Language: English
• Published: United States 01.01.2019
• Subjects: Adult; Anti-Retroviral Agents - therapeutic use; Drug Administration Schedule; Female; HIV Infections - drug therapy; HIV Infections - transmission; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical - prevention & control; Malawi - epidemiology; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Pregnancy Complications, Infectious - epidemiology; Pregnancy Complications, Infectious - prevention & control; Pregnancy Outcome; Prospective Studies; Socioeconomic Factors; Malawi
• ISSN: 1944-7884
• DOI: 10.1097/QAI.0000000000001875

Adverse pregnancy outcomes such as preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) remain major global problems. We compared pregnancy outcomes among HIV-infected women receiving antiretroviral treatment (ART) and with CD4 ≥350 cells, and HIV-uninfected women to assess whether disparities associated with HIV infection have been eliminated through use of ART. Observational study conducted at 5 health facilities in Blantyre, Malawi, during 2016-2017. HIV-infected women receiving the national ART regimen (efavirenz + lamivudine + tenofovir) and HIV-uninfected women were consented and enrolled at delivery. Data collected included sociodemographic and clinical; gestational age; BW; infant/maternal anthropometry; and laboratory results. We defined PTB as GA <37 weeks; LBW as BW <2·5 kg; and SGA as BW <10th percentile of GA. SGA infants were classified into proportionate and disproportionate based on ponderal index. Descriptive, stratified, and multivariate logistic and linear regression analyses were used. Of 5423 women approached, 614 HIV-infected and 685 HIV-uninfected women were enrolled. Rates of PTB, LBW, and SGA were 10.6%, 7.2%, and 17.1% among HIV-infected women on ART and 9.5%, 5.0%, and 18.4% among HIV-uninfected women, respectively. None of these differences were statistically significant in univariate- or multivariate-adjusted analyses (P > 0.05). Of 231 SGA infants, 78.8% were proportionate and 21% were disproportionate. Of the 614 HIV-infected women on ART, 75% had undetectable virus at delivery. ART use has reduced the high rates of adverse pregnancy outcomes among HIV-infected women. However, the rates remain high irrespective of HIV infection and require appropriate interventions.