Sclerotherapy for gastric fundal variceal bleeding: Is complete obliteration possible without cyanoacrylate?

• Published in: Journal of gastroenterology and hepatology Vol. 20; no. 11; pp. 1701 - 1706
• Main Authors: KOJIMA, KUNIYUKI, IMAZU, HIROO, MATSUMURA, MASAHIKO, HONDA, YASUHIRO, UMEMOTO, NORIE, MORIYASU, HIROHITO, ORIHASHI, TORU, UEJIMA, MASANOBU, MORIOKA, CHIE, KOMEDA, YORIAKI, UEMURA, MASATO, YOSHIJI, HITOSHI, FUKUI, HIROSHI
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.11.2005; Blackwell Science
• Subjects: Adult; Aged; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; cyanoacrylate; Cyanoacrylates - therapeutic use; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Esophageal and Gastric Varices - therapy; Feasibility Studies; Female; gastric fundal variceal bleeding; Gastric Fundus; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Hemorrhage - mortality; Gastrointestinal Hemorrhage - therapy; Hemostasis, Endoscopic; Hemostatics - therapeutic use; Humans; Male; Medical sciences; Middle Aged; Nitroglycerin - therapeutic use; Oleic Acids - therapeutic use; Recurrence; Sclerosing Solutions - therapeutic use; sclerotherapy; Sclerotherapy - adverse effects; Sclerotherapy - methods; Survival Analysis; Treatment Outcome; Vasopressins - therapeutic use; Vascular disease; Stomach; gastric fundal variceal bleeding; Gastroenterology; Cardiovascular disease; Obliteration; Hemorrhage; Sclerotherapy; Sclerosis; Venous disease; Varix; cyanoacrylate
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/j.1440-1746.2005.03992.x

Background:  Many studies have suggested that endoscopic obliteration using cyanoacrylate for bleeding gastric fundal varices is effective. However, serious complications by injection of cyanoacrylate into varices have also been reported. Methods:  Thirty patients with bleeding gastric fundal varices underwent endoscopic injection sclerotherapy using 5% ethanolamine oleate under fluoroscopic guidance plus infusion of vasopressin and a transdermal nitroglycerin patch. The injection of 5% ethanolamine oleate was continued until it filled the varices and their feeder veins under fluoroscopic guidance. The injection needle was removed while thrombin glue was sprayed at the puncture site through the side hole of the injector needle to prevent bleeding from the puncture site. Results:  Complete hemostasis was achieved in 28/30 patients (93.3%). The cumulative rebleeding rate after 1, 3 and 5 years was 13%, 19% and 19%, respectively. The 1‐, 3‐, and 5‐year cumulative mortality rates were 31%, 54% and 59%, respectively. There was no complication related to infusion of vasopressin and sclerotherapy procedure. Conclusion:  The sclerotherapy method carried out using 5% ethanolamine oleate combined with infusion of vasopressin under fluoroscopic guidance might be a feasible method for obliteration of gastric fundal varices as an alternative to cyanoacrylate.