Lipidomic Profiling Identifies a Novel Lipid Signature Associated with Ethnicity-Specific Disparity of Bladder Cancer

Bladder Cancer (BLCA) is the ninth most frequently diagnosed cancer globally and the sixth most common cancer in the US. African Americans (AA) exhibit half the BLCA incidence compared to European Americans (EA), but they have a 70% higher risk of cancer-related death; unfortunately, this disparity...

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Published inMetabolites Vol. 12; no. 6; p. 544
Main Authors Kami Reddy, Karthik Reddy, Piyarathna, Danthasinghe Waduge Badrajee, Kamal, Abu Hena Mostafa, Putluri, Vasanta, Ravi, Shiva Shankar, Bollag, Roni J, Terris, Martha K, Lotan, Yair, Putluri, Nagireddy
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.06.2022
MDPI
Subjects
Bladder cancer
Cancer
Cell division
Chromatography
Ethnicity
ethnicity-specific disparity
Fatty acids
Health disparities
lipidomics
Lipids
Mass spectrometry
Medical prognosis
Metabolism
Metabolites
Minority & ethnic groups
Mortality
Phosphatidylethanolamine
Scientific imaging
Tumors
bladder cancer
ethnicity-specific disparity
lipidomics
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Summary:Bladder Cancer (BLCA) is the ninth most frequently diagnosed cancer globally and the sixth most common cancer in the US. African Americans (AA) exhibit half the BLCA incidence compared to European Americans (EA), but they have a 70% higher risk of cancer-related death; unfortunately, this disparity in BLCA mortality remains poorly understood. In this study, we have used an ethnicity-balanced cohort for unbiased lipidomics profiling to study the changes in the lipid fingerprint for AA and EA BLCA tissues collected from similar geographical regions to determine a signature of ethnic-specific alterations. We identified 86 lipids significantly altered between self-reported AA and EA BLCA patients from Augusta University (AU) cohort. The majority of altered lipids belong to phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), ly sophosphatidylcholines (lysoPCs), phosphatidylserines (PSs), and diglycerides (DGs). Interestingly, levels of four lysoPCs (lyso PCs 20:3, lyso PCs 22:1, lyso PCs 22:2, and lyso PCs 26:1) were elevated while, in contrast, the majority of the PCs were reduced in AA BLCA. Significant alterations in long-chain monounsaturated (MonoUN) and polyunsaturated (PolyUN) lipids were also observed between AA and EA BLCA tumor tissues. These first-in-field results implicate ethnic-specific lipid alterations in BLCA.
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These authors contributed equally to this work.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo12060544