Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study

• Published in: International journal of environmental research and public health Vol. 16; no. 22; p. 4350
• Main Authors: Min, Kyoung-Bok, Min, Jin-Young
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.11.2019; MDPI
• Subjects: Aged; Aged, 80 and over; Antigens; Blood pressure; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - immunology; Cardiovascular Diseases - mortality; Cohort analysis; Cohort Studies; Coronary artery; Coronary artery disease; Diabetes; Enzymes; Female; Food allergies; Health risk assessment; Health risks; Humans; Hypertension; Hypotheses; Immunoglobulin E - blood; Immunologic Tests; Male; Middle Aged; Mortality; Myocardial Infarction; Nutrition Surveys; Older people; Physical activity; Population; Population studies; Population-based studies; Prospective Studies; Risk Factors; Secondary schools; Smoking; Studies; United States - epidemiology; United States; United States > US; cardiovascular disease; cause of death; immunoglobulin E; population-based cohort; premature death
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph16224350

Despite a potential link between immunoglobulin E (IgE) levels and cardiovascular disease, the effect of elevated total IgE levels on long-term mortality risk remains unclear. We prospectively investigated the association between total serum IgE levels and all-cause and cardiovascular mortality in US adults. We analyzed data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES) and the NHANES (2005-2006) Linked Mortality Public File. The 2005-2006 NHANES data of 1496 older adults aged ≥50 years and who underwent a serum total IgE antibody test in the initial survey were included. After a median follow-up of 119 months, a significant association was observed between total serum IgE levels and cardiovascular mortality, with subjects with the highest total IgE exhibiting a 3.19-fold (HR = 3.19; 95% confidence interval: 1.71-5.96) increase in the risk of cardiovascular mortality compared with those with the lowest total IgE (≤16.80 kU/L). Furthermore, the mortality rate increased with an increase in total IgE levels, regardless of baseline history of cardiovascular diseases (e.g., myocardial infarction, stroke, and noninvasively diagnosed large-vessel peripheral arterial disease). This finding suggests that the elevation of IgE levels may be a risk factor for increased cardiovascular mortality.