Prevalence of chronic kidney disease and associated factors in Chinese individuals with type 2 diabetes: Cross-sectional study

• Published in: Journal of diabetes and its complications Vol. 30; no. 5; pp. 803 - 810
• Main Authors: Guo, Kaifeng, Zhang, Lei, Zhao, Fangya, Lu, Junxi, Pan, Pan, Yu, Haoyong, Bao, Yuqian, Chen, Haibing, Jia, Weiping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016; Elsevier Limited
• Subjects: Aged; Albuminuria; Albuminuria - etiology; Blood pressure; Body mass index; China - epidemiology; Cholesterol; Chronic kidney disease; Cohort Studies; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetic kidney disease; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - physiopathology; Diabetic Nephropathies - urine; Diabetic retinopathy; Endocrinology & Metabolism; Fasting; Female; Glomerular Filtration Rate; Glucose; Hospitals, University; Humans; Hyperfiltration; Hypertension; Kidney - physiopathology; Kidney diseases; Lipoproteins; Male; Mens health; Middle Aged; Prevalence; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - physiopathology; Renal Insufficiency, Chronic - urine; Reproducibility of Results; Risk Factors; Severity of Illness Index; Sex Factors; Triglycerides; Type 2 diabetes; Uric acid; Womens health; China; Type 2 diabetes; Chronic kidney disease; Prevalence; Albuminuria; Hyperfiltration; Diabetic kidney disease
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2016.03.020

Abstract Aims This cross-sectional study aimed to determine the prevalence and associated risk factors of chronic kidney disease (CKD) in Chinese type 2 diabetic patients. Methods A total of 3301 patients with type 2 diabetes were included in this study. Anthropometric parameters and biochemical indices were measured. The main outcome measures were detection of CKD, albuminuria and estimated glomerular filtration rate (eGFR). Results The prevalence of CKD and albuminuria in Shanghai Chinese type 2 diabetic patients was 27.1% and 25.2%. The prevalence of mildly decreased renal function or worse (eGFR < 60/mL/min/1.73 m2 ) was 6%. The prevalence of glomerular hyperfiltration was 12.2%. The prevalence of diabetic kidney disease (DKD) according to the newest NKF’s KDOQI classification was 12.03%. Risk factors associated with DKD were SBP, retinopathy, neuropathy, TG, LDL, anemia and HbA1c. Clinical factors associated with both albuminuria and low eGFR (≥ 60/< 60) were SBP, retinopathy, TC, TG and anemia. Conclusion In conclusion, CKD and DKD were common in the Shanghai Chinese patients with T2DM and were similar to that in Western patients. Prevention and control of diabetes should be a high priority in reducing the CKD burden in China.