Rivaroxaban and intracranial haemorrhage after mild traumatic brain injury: A dangerous combination?

Highlights • Novel anticoagulants such as rivaroxaban are increasingly prescribed. • We retrospectively analyze patients with mild TBI and intracranial haemorrhage. • Rivaroxaban treatment increased mortality and rate of re-haemorrhage. • Lack of specific antidotes may contribute to unfavourable out...

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Bibliographic Details
Published inClinical neurology and neurosurgery Vol. 136; pp. 73 - 78
Main Authors Beynon, Christopher, Potzy, Anna, Sakowitz, Oliver W, Unterberg, Andreas W
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2015
Elsevier Limited
Subjects
Adult
Aged
Aged, 80 and over
Anticoagulants
Anticoagulants, Factor Xa inhibitors, Haemostasis, Intracerebral haemorrhage
Brain Injuries - complications
Brain Injuries - surgery
Cardiovascular disease
Factor Xa Inhibitors - therapeutic use
Female
Head injury
Humans
Intracranial Hemorrhage, Traumatic - complications
Intracranial Hemorrhage, Traumatic - drug therapy
Intracranial Hemorrhages - drug therapy
Intracranial Hemorrhages - etiology
Male
Middle Aged
Mortality
Neurology
Neurosurgery
Platelet Aggregation Inhibitors - therapeutic use
Retrospective Studies
Rivaroxaban - therapeutic use
Traumatic brain injury
Treatment Outcome
Head injury
Anticoagulants, Factor Xa inhibitors, Haemostasis, Intracerebral haemorrhage
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Summary:Highlights • Novel anticoagulants such as rivaroxaban are increasingly prescribed. • We retrospectively analyze patients with mild TBI and intracranial haemorrhage. • Rivaroxaban treatment increased mortality and rate of re-haemorrhage. • Lack of specific antidotes may contribute to unfavourable outcome.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2015.05.035