Recombinant fowlpox viruses inducing protective immunity against Newcastle disease and fowlpox viruses

• Published in: Vaccine Vol. 8; no. 5; pp. 486 - 490
• Main Authors: Ogawa, Ryohei, Yanagida, Noboru, Saeki, Sakiko, Saito, Shuji, Ohkawa, Setsuko, Gotoh, Hiroyuki, Kodama, Kazumi, Kamogawa, Kouichi, Sawaguchi, Kazunari, Iritani, Yoshikazu
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.1990; Elsevier
• Subjects: Animals; Base Sequence; Biological and medical sciences; Chickens; fowlpox; Fowlpox - prevention & control; Fowlpox virus - genetics; Fowlpox virus - immunology; Fundamental and applied biological sciences. Psychology; Hemagglutination Inhibition Tests; Hemagglutinins, Viral - genetics; Microbiology; Molecular Sequence Data; Neuraminidase - genetics; Newcastle disease; Newcastle Disease - immunology; Newcastle Disease - prevention & control; Newcastle disease virus; Newcastle disease virus - genetics; Newcastle disease virus - immunology; recombinant DNA; Specific Pathogen-Free Organisms; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Virology; recombinant DNA; Newcastle disease; fowlpox; Immunoprotection; Chordopoxvirinae; Immunization; Recombinant virus; Hemagglutinin; Newcastle virus; Recombinant DNA; Paramyxoviridae; Virus; Vertebrata; Avipoxvirus; Gene; Poxviridae; Neuraminidase; Chicken; Aves; Paramyxovirus
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/0264-410X(90)90251-G

The haemagglutinin-neuraminidase gene of Newcastle disease virus was inserted into a non-essential region of the fowlpox virus genome and expressed under control of the vaccinia virus 7.5 kDa polypeptide gene promoter. Immunization with the recombinant fowlpox virus elicited protective immunity in chickens against both virulent Newcastle disease and fowlpox virus infection.