Lower Geriatric Nutritional Risk Index and Prognostic Nutritional Index Predict Postoperative Prognosis in Patients with Hepatocellular Carcinoma

• Published in: Nutrients Vol. 16; no. 7; p. 940
• Main Authors: Tsukagoshi, Mariko, Araki, Kenichiro, Igarashi, Takamichi, Ishii, Norihiro, Kawai, Shunsuke, Hagiwara, Kei, Hoshino, Kouki, Seki, Takaomi, Okuyama, Takayuki, Fukushima, Ryosuke, Harimoto, Norifumi, Shirabe, Ken
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.03.2024
• Subjects: Aged; Body mass index; Cancer therapies; Carcinoma, Hepatocellular - surgery; geriatric nutritional risk index; Geriatrics; Hepatitis B; Hepatitis C; hepatocellular carcinoma; Hepatoma; Humans; Liver cancer; Liver Neoplasms - surgery; liver resection; Lymphocytes; Medical prognosis; Medical research; Medicine, Experimental; Muscles; Nutrition Assessment; Nutritional status; Patients; Physiological aspects; Prognosis; prognostic nutritional index; Proteins; Radiation therapy; recurrence; Retrospective Studies; Surgery; Tumors; recurrence; liver resection; prognostic nutritional index; prognosis; hepatocellular carcinoma; geriatric nutritional risk index
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16070940

Increasing evidence suggests that nutritional indices, including the geriatric nutritional risk index (GNRI) and prognostic nutritional index (PNI), are predictors of poor prognosis in patients with hepatocellular carcinoma (HCC). Hence, this study aimed to explore the value of the GNRI and PNI in evaluating postoperative prognosis in patients with HCC, particularly regarding its recurrence patterns. We performed a retrospective analysis of 203 patients with HCC who underwent initial hepatic resection. Patients were divided into two groups according to the GNRI (cutoff: 98) and PNI (cutoff: 45). The GNRI and PNI were significantly associated with body composition (body mass index and skeletal muscle mass index), hepatic function (Child-Pugh Score), tumor factors (tumor size and microvascular invasion), and perioperative factors (blood loss and postoperative hospitalization). Patients with a low PNI or low GNRI had significantly worse overall survival (OS) and recurrence-free survival. Patients with early recurrence had lower PNI and GNRI scores than those without early recurrence. Patients with extrahepatic recurrence had lower PNI and GNRI scores than those without extrahepatic recurrence. The PNI and GNRI might be useful in predicting the prognosis and recurrence patterns of patients with HCC after hepatic resection.