Exclusive detection of cerebral hemodynamics in functional near-infrared spectroscopy by reflectance modulation of the scalp surface

• Published in: Journal of biomedical optics Vol. 25; no. 8; p. 087001
• Main Authors: Kawaguchi, Hiroshi, Tanikawa, Yukari, Yamada, Toru
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.08.2020; S P I E - International Society for
• Subjects: Absorption; Cerebral cortex; Cerebrum; Computer simulation; Contamination; Feasibility studies; Hemodynamic responses; Hemodynamics; Hemoglobin; Infrared spectra; Infrared spectroscopy; Light; Localization; Mathematical analysis; Medical imaging; Methods; Modulation; Near infrared radiation; Neonates; Optical properties; Physiology; Propagation; Reflectance; Scalp; Sensing; Sensors; Simulation; Spectrum analysis; Surface chemistry; reflectance modulation; signal contamination; partial optical path length; functional near-infrared spectroscopy; scalp blood flow
• ISSN: 1083-3668; 1560-2281
• DOI: 10.1117/1.JBO.25.8.087001

Significance: Functional near-infrared spectroscopy (fNIRS) is a technique for detecting regional hemodynamic responses associated with neural activation in the cerebral cortex. The absorption changes due to hemodynamic changes in the scalp cause considerable signal contamination in the fNIRS measurement. A method for extracting hemodynamic changes in the cerebral tissue is required for reliable fNIRS measurement. Aim: To exclusively detect cerebral functional hemodynamic changes, we developed an fNIRS technique using reflectance modulation of the scalp surface. Approach: The theoretical feasibility of the proposed method was proven by a simulation calculation of light propagation. Its practical feasibility was evaluated by a phantom experiment and brain activation simulation mimicking human fNIRS experiments. Results: The simulation calculation revealed that the partial path length of the scalp was changed by reflectance modulation of the scalp surface. The influence of absorption change in the superficial layer was successfully reduced by the proposed method, using only measurement data, in the phantom experiment. The proposed method was applicable to human experiments of standard designs, achieving statistical significance within an acceptable experimental time-frame. Conclusions: Removal of the scalp hemodynamic effect by the proposed technique will increase the quality of fNIRS data, particularly in measurements in neonates and infants that typically would require a dense optode arrangement.